GNAT3

Из Википедије, слободне енциклопедије
Vezujući protein guaninskog nukleotida, alfa jedinica 3
Identifikatori
Simboli GNAT3; GDCA
Vanjski ID OMIM139395 MGI3588268 HomoloGene24284 GeneCards: GNAT3 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 346562 242851
Ensembl ENSG00000214415 ENSMUSG00000028777
UniProt A8MTJ3 Q3V3I2
RefSeq (mRNA) NM_001102386.1 NM_001081143.1
RefSeq (protein) NP_001095856.1 NP_001074612.1
Lokacija (UCSC) Chr 7:
80.09 - 80.14 Mb
Chr 5:
17.47 - 17.53 Mb
PubMed pretraga [1] [2]

Vezujući protein guaninskog nukleotida G(t), alfa jedinica 3 (gustducin alfa-3 lanac) je protein koji je kod ljudi kodiran GNAT3 genom.[1]

Gustducin alfa-3 lanac je podjedinica heterotrimerinog proteina gustducina koji je odgovoran za osnovne ukuse.

Reference[уреди]

Literatura[уреди]

  • Oldham WM, Van Eps N, Preininger AM; et al. (2006). „Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.”. Nat. Struct. Mol. Biol. 13 (9): 772—7. doi:10.1038/nsmb1129. PMID 16892066. 
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767—72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Rozengurt N, Wu SV, Chen MC; et al. (2006). „Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.”. Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792—802. doi:10.1152/ajpgi.00074.2006. PMID 16728727. 
  • Huang L, Shanker YG, Dubauskaite J; et al. (1999). „Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.”. Nat. Neurosci. 2 (12): 1055—62. doi:10.1038/15981. PMID 10570481. 
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157—64. doi:10.1038/nature01782. PMID 12853948. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239—64. doi:10.1007/s12033-008-9031-1. PMID 18240029. 
  • Margolskee RF, Dyer J, Kokrashvili Z; et al. (2007). „T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075—80. doi:10.1073/pnas.0706678104. PMID 17724332. 
  • Takami S, Getchell TV, McLaughlin SK; et al. (1994). „Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.”. Brain Res. Mol. Brain Res. 22 (1-4): 193—203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379. 
  • Jang HJ, Kokrashvili Z, Theodorakis MJ; et al. (2007). „Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069—74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMID 17724330. 
  • Li X, Staszewski L, Xu H; et al. (2002). „Human receptors for sweet and umami taste.”. Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692—6. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125. 
  • Fehr J, Meyer D, Widmayer P; et al. (2007). „Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.”. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21—34. doi:10.1007/s00359-006-0168-8. PMID 17021831. 
  • Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). „Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.”. Nature 369 (6482): 621—8. doi:10.1038/369621a0. PMID 8208289.