Gama-Renin
| Gama-Renin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.54 | ||||||||
| CAS broj | 85270-20-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Gama-Renin (EC 3.4.21.54, Gamma-renin) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Leu-Leu veze u sintetičkom tetradekapeptidu reninskog supstrata (konj), čime se formira angiotensin I, ali ne i aktivni prirodni angiotenzinogen, za razliku od renina (EC 3.4.23.15). Takođe dolazi do hidrolize Bz-Arg-p-nitroanilida
Ovaj enzim je član tkivne kalikreinske familije.
Reference[уреди | уреди извор]
- ^ Poe, M., Wu, J.K., Florance, J.R., Rodkey, J.A., Bennett, C.D. and Hoogsteen, K. (1983). „Purification and properties of renin and γ-renin from the mouse submaxillary gland”. J. Biol. Chem. 258: 2209—2216. PMID 6337154.
- ^ Drinkwater, C.C., Evans, B.A. and Richards, R.I. (1988). „Sequence and expression of mouse γ-renin”. J. Biol. Chem. 263: 8565—8568. PMID 3288617.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Gamma-renin на US National Library of Medicine Medical Subject Headings (MeSH)
