Gentamicin 2"-nukleotidiltransferaza
| Gentamicin 2"-nukleotidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.46 | ||||||||
| CAS broj | 62213-33-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gentamicin 2"-nukleotidiltransferaza (EC 2.7.7.46, gentamicin 2-adenililtransferaza, aminoglikozidna adenililtransferaza, gentamicinska 2-nukleotidiltransferaza) je enzim sa sistematskim imenom NTP:gentamicin 2-nukleotidiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nukleozid trifosfat + gentamicin difosfat + 2-nukleotidilgentamicin
ATP, dATP, CTP, ITP i GTP mogu da deluju kao donori; kanamicin, tobramicin i sizomicin takođe deluju kao akceptori.
Reference[уреди | уреди извор]
- ^ Angelatou, F., Litsas, S.B. and Kontomichalou, P. (1982). „Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa”. J. Antibiot. 35: 235—244. PMID 6281224.
- ^ Naganawa, H., Yagisawa, M., Kondo, S., Takeuchi, T. and Umezawa, H. (1971). „The structure determination of an enzymatic inactivation product of 3′,4′-dideoxykanamycin B”. J. Antibiot. 24: 913—914. PMID 4946513.
- ^ Yagisawa, M., Naganawa, H., Kondo, S., Hamada, M., Takeuchi, T. and Umezawa, H. (1971). „Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor”. J. Antibiot. 24: 911—912. PMID 4946512.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- -nucleotidyltransferase Gentamicin+2-nucleotidyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
