Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična)
| Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.83 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Heksaprenil-difosfat sintaza ((2E,6E)-farnezil-difosfat specifična) (EC 2.5.1.83, HexPS, heksaprenil pirofosfatna sintetaza, heksaprenil difosfatna sintaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat farneziltranstransferaza (dodaje 3 izopentenilne jedinice).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + 3 izopentenil difosfat 3 difosfat + sve-trans-heksaprenil difosfat
Ovaj enzim preferentno deluje na geranilgeranil difosfat.
Reference[уреди | уреди извор]
- ^ Fujii, H., Koyama, T. and Ogura, K. (1982). „Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components”. J. Biol. Chem. 257: 14610—14612. PMID 7174655.
- ^ Shimizu, N., Koyama, T. and Ogura, K. (1998). „Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase”. J. Bacteriol. 180: 1578—1581. PMID 9515931.
- ^ Nagaki, M., Kimura, K., Kimura, H., Maki, Y., Goto, E., Nishino, T. and Koyama, T. (2001). „Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases”. Bioorg. Med. Chem. Lett. 11: 2157—2159. PMID 11514159.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Hexaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific) на US National Library of Medicine Medical Subject Headings (MeSH)
