Hinolinat sintaza
| Hinolinat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.72 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hinolinat sintaza (EC 2.5.1.72, NadA, QS, hinolinatna sintetaza) je enzim sa sistematskim imenom gliceron fosfat:iminosukcinatna alkiltransferaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- gliceron fosfat + iminozukcinat piridin-2,3-dikarboksilat + 2H2O + fosfat
Ovah gvožđe-sumporni protein sadrži [4Fe-4S] klaster.
Reference[уреди | уреди извор]
- ^ Ollagnier-de Choudens, S., Loiseau, L., Sanakis, Y., Barras, F. and Fontecave, M. (2005). „Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis”. FEBS Lett. 579: 3737—3743. PMID 15967443.
- ^ Katoh, A., Uenohara, K., Akita, M. and Hashimoto, T. (2006). „Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid”. Plant Physiol. 141: 851—857. PMID 16698895.
- ^ Sakuraba, H., Tsuge, H., Yoneda, K., Katunuma, N. and Ohshima, T. (2005). „Crystal structure of the NAD biosynthetic enzyme quinolinate synthase”. J. Biol. Chem. 280: 26645—26648. PMID 15937336.
- ^ Rousset, C., Fontecave, M. and Ollagnier de Choudens, S. (2008). „The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: Investigation of cluster ligands”. FEBS Lett. 582: 2937—2944. PMID 18674537.
- ^ Saunders, A.H. & Booker, S.J. (2008). „Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation”. Biochemistry. 47: 8467—8469. PMID 18651751.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Quinolinate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
