Holesterol 25-hidroksilaza
| Holesterol 25-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.38 | ||||||||
| CAS broj | 60202-07-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Holesterol 25-hidroksilaza (EC 1.14.99.38, holesterolna 25-monooksigenaza) je enzim sa sistematskim imenom holesterol,vodonik-donor:kiseonik oksidoreduktaza (25-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- holesterol + AH2 + O2 25-hidroksiholesterol + A + H2O
Za razliku od većine drugih sterolnih hidroksilaza, ovaj enzim nije citohrom P-450. On koristi kofaktore sa dva atoma gvožđa da katalizuje hidroksilaciju hidrofobnih supstrata.
Reference[уреди | уреди извор]
- ^ Lund, E.G., Kerr, T.A., Sakai, J., Li, W.P. and Russell, D.W. (1998). „cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism”. J. Biol. Chem. 273: 34316—34327. PMID 9852097.
- ^ Chen, J.J., Lukyanenko, Y. and Hutson, J.C. (2002). „25-Hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro”. Biol. Reprod. 66: 1336—1341. PMID 11967195.
- ^ Lukyanenko, Y., Chen, J.J. and Hutson, J.C. (2002). „Testosterone regulates 25-hydroxycholesterol production in testicular macrophages”. Biol. Reprod. 67: 1435—1438. PMID 12390873.
- ^ Fox, B.G., Shanklin, J., Ai, J., Loehr, T.M. and Sanders-Loehr, J. (1994). „Resonance Raman evidence for an Fe-O-Fe center in stearoyl-ACP desaturase. Primary sequence identity with other diiron-oxo proteins”. Biochemistry. 33: 12776—12786. PMID 7947683.
- ^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Cholesterol+25-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
