Komponenta komplementa 3

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Komponenta komplementa 3
PDB prikaz baziran na 1c3d.
Dostupne strukture
1c3d, 1ghq, 1w2s, 2a73, 2a74, 2b39, 2gox, 2hr0, 2i07, 2ice, 2icf
Identifikatori
Simboli C3; ASP; CPAMD1
Vanjski ID OMIM120700 MGI88227 HomoloGene68031 GeneCards: C3 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 718 12266
Ensembl ENSG00000125730 ENSMUSG00000024164
UniProt P01024 Q207D2
RefSeq (mRNA) NM_000064 NM_009778
RefSeq (protein) NP_000055 NP_033908
Lokacija (UCSC) Chr 19:
6.68 - 6.73 Mb
Chr 17:
56.89 - 56.91 Mb
PubMed pretraga [1] [2]

Komponenta komplementa 3 (C3) je protein imunskog sistema. On ima centralnu ulogu u sistemu komplementa i doprinosi urođenoj imunosti. Kod ljudi je on kodiran na hromozomu 19 C3 genom.[1][2]

Funkcija[уреди]

C3 ima centralnu mesto u aktivaciji sistema komplementa.[3] Njegova aktivacija je neophodna u putevima aktivacije klasičnog i alternativnnog komplementa. Ljudi sa C3 deficijencijom su podložni bakterijskim infekcijama.[4][5]

Struktura[уреди]

Nekoliko C3 kristalnih struktura je rešeno.[6] Ovaj protein se sastoji od 13 domena.[7][8][9][10]

Interakcije[уреди]

Za komponenta komplementa 3 je pokazano da interaguje sa faktorom H.[11][12]

Literatura[уреди]

  1. de Bruijn MH, Fey GH (February 1985). „Human complement component C3: cDNA coding sequence and derived primary structure”. Proc. Natl. Acad. Sci. U.S.A. 82 (3): 708–12. DOI:10.1073/pnas.82.3.708. PMC 397115. PMID 2579379. 
  2. „Entrez Gene: C3 complement component 3”. 
  3. Sahu A, Lambris JD (April 2001). „Structure and biology of complement protein C3, a connecting link between innate and acquired immunity”. Immunol. Rev. 180: 35–48. DOI:10.1034/j.1600-065X.2001.1800103.x. PMID 11414361. 
  4. Lachmann P (December 1975). „Genetics of the complement system”. J. Med. Genet. 12 (4): 372–7. DOI:10.1136/jmg.12.4.372. PMC 1013316. PMID 768477. 
  5. Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M (December 2001). „Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters”. Intern. Med. 40 (12): 1254–8. DOI:10.2169/internalmedicine.40.1254. PMID 11813855. 
  6. „Advanced search results for UniProt accession P01024”. Protein Data Bank in Europe (PDBe). European Bioinformatics Institute. Приступљено 27. 12. 2010.. 
  7. Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, Nilsson B, Gros P (September 2005). „Structures of complement component C3 provide insights into the function and evolution of immunity”. Nature 437 (7058): 505–11. DOI:10.1038/nature04005. PMID 16177781. 
  8. Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P (November 2006). „Structure of C3b reveals conformational changes that underlie complement activity”. Nature 444 (7116): 213–6. DOI:10.1038/nature05172. PMID 17051160. 
  9. Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M (November 2006). „Structure of C3b in complex with CRIg gives insights into regulation of complement activation”. Nature 444 (7116): 217–20. DOI:10.1038/nature05263. PMID 17051150. 
  10. Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L (August 2006). „The structure of bovine complement component 3 reveals the basis for thioester function”. J. Mol. Biol. 361 (1): 115–27. DOI:10.1016/j.jmb.2006.06.009. PMID 16831446. 
  11. Soames, C J; Sim R B (Sep. 1997). „Interactions between human complement components factor H, factor I and C3b”. Biochem. J. (ENGLAND) 326 ( Pt 2): 553–61. ISSN 0264-6021. PMC 1218704. PMID 9291131. 
  12. Jokiranta, T S; Westin J, Nilsson U R, Nilsson B, Hellwage J, Löfås S, Gordon D L, Ekdahl K N, Meri S (Mar. 2001). „Complement C3b interactions studied with surface plasmon resonance technique”. Int. Immunopharmacol. (Netherlands) 1 (3): 495–506. DOI:10.1016/S1567-5769(00)00042-4. ISSN 1567-5769. PMID 11367533. 

Dodatna literatura[уреди]

  • Bradley, D T; Zipfel, P F; Hughes, A E (2011). „Complement in age-related macular degeneration: a focus on function”. Eye. DOI:10.1038/eye.2011.37. 

Spoljašnje veze[уреди]