Makrocin O-metiltransferaza
| Makrocin O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.101 | ||||||||
| CAS broj | 79468-52-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Makrocin O-metiltransferaza (EC 2.1.1.101, makrocinska metiltransferaza, S-adenozil-L-metionin-makrocinska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:makrocin 3'-O-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
3-hidroksi grupa 2-O-metil-6-dezoksi-D-aloznog ostatka u makrolidnom antibiotiku makrozinu deluje kao metil akceptor. Ovaj enzim takođe konvertuje laktenozin u desmikocin.
Reference[уреди | уреди извор]
- ^ Bauer, N.J., Kreuzman, A.J., Dotzlaf, J.E. and Yeh, W.-K. (1988). „Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae”. J. Biol. Chem. 263: 15619—15625. PMID 3170601.
- ^ Kreuzman, A.J., Turner, J.R. and Yeh, W.-K. (1988). „Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism”. J. Biol. Chem. 263: 15626—15633. PMID 3170602.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Macrocin+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
