Metilisana-tiol-koenzim M metiltransferaza
| Metilisana-tiol-koenzim M metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.251 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Metilisana-tiol-koenzim M metiltransferaza (EC 2.1.1.251, mtsA (gen)) je enzim sa sistematskim imenom metilated-tiol:koenzim M metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- metantiol + koenzim M metil-KoM + vodonik sulfid (sveukupna reakcija)
- (1a) metantiol + [Co(I) metilisani-tiol-specifični korinoidni protein] [metil-Co(III) metilisani-tiol-specifični korinoidni protein] + vodonik sulfid
- (1b) [metil-Co(III) metilisani-tiol-specifični korinoidni protein] + koenzim M metil-KoM + [Co(I) metilisani-tiol-specifični korinoidni protein]
Ovaj enzim učestvuje u metanogenezi metilisanih tiola, poput metan tiola, dimetil sulfida, i 3-S-metilmerkaptopropionata.
Reference[уреди | уреди извор]
- ^ Paul, L. & Krzycki, J.A. (1996). „Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase”. J. Bacteriol. 178: 6599—6607. PMID 8932317.
- ^ Tallant, T.C. & Krzycki, J.A. (1997). „Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate”. J. Bacteriol. 179: 6902—6911. PMID 9371433.
- ^ Tallant, T.C., Paul, L. and Krzycki, J.A. (2001). „The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer”. J. Biol. Chem. 276: 4485—4493. PMID 11073950.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Methylated-thiol---coenzyme+M+methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
