Nitrazepam

Nitrazepam
IUPAC ime
	7-nitro-5-fenil-2,3-dihidro-1H-1,4-benzodiazepin-2-on
Klinički podaci
Prodajno ime	Alodorm, Apo-nitrazepam tablets BP, Apodorm, Benzalin
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	15-38 sati
Identifikatori
CAS broj	146-22-5
ATC kod	N05CD03 (WHO), N05CD02
PubChem	CID 4506
DrugBank	DB01595
ChemSpider	4350
KEGG	C07487
Hemijski podaci
Formula	C15H11N3O3
Molarna masa	281.2661
	SMILES [O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2)C=C1; ;
	InChI InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19) ; Key:KJONHKAYOJNZEC-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	225 °C (437 °F)

Nitrazepam je benzodiazepinski derivat koji se koristi kao antikonvulsant i hipnotik.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Reference

^ Rickels, K. (1986). „The clinical use of hypnotics: Indications for use and the need for a variety of hypnotics”. Acta Psychiatrica Scandinavica. Supplementum. 332: 132—141. PMID 2883820. doi:10.1111/j.1600-0447.1986.tb08990.x.
^ Robertson, M. D.; Drummer, O. H. (1995 May). „Postmortem drug metabolism by bacteria”. Journal of Forensic Sciences. 40 (3): 382—6. PMID 7782744. doi:10.1520/JFS13791J. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Oelschläger, H. (1989). „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.
^ Podhorna, J.; Krsiak, M. (2000 Apr). „Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice”. Behavioural Pharmacology. 11 (2): 143—51. PMID 10877119. doi:10.1097/00008877-200004000-00006. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Nowakowska, E.; Chodera, A. (1991 Feb). „Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats”. Pharmacology, Biochemistry, and Behavior. 38 (2): 265—6. PMID 1676167. doi:10.1016/0091-3057(91)90276-8. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

Spoljašnje veze

Nitrazepam

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rickels, K. (1986). „The clinical use of hypnotics: Indications for use and the need for a variety of hypnotics”. Acta Psychiatrica Scandinavica. Supplementum. 332: 132—141. PMID 2883820. doi:10.1111/j.1600-0447.1986.tb08990.x.

[2] Robertson, M. D.; Drummer, O. H. (1995 May). „Postmortem drug metabolism by bacteria”. Journal of Forensic Sciences. 40 (3): 382—6. PMID 7782744. doi:10.1520/JFS13791J. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Oelschläger, H. (1989). „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.

[4] Podhorna, J.; Krsiak, M. (2000 Apr). „Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice”. Behavioural Pharmacology. 11 (2): 143—51. PMID 10877119. doi:10.1097/00008877-200004000-00006. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Nowakowska, E.; Chodera, A. (1991 Feb). „Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats”. Pharmacology, Biochemistry, and Behavior. 38 (2): 265—6. PMID 1676167. doi:10.1016/0091-3057(91)90276-8. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[6] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

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