O-sukcinilbenzoat-KoA ligaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

O-sukcinilbenzoat-KoA ligaza
O-sukcinilbenzoat-KoA ligaza
Identifikatori
EC broj	6.2.1.26
CAS broj	72506-70-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

O-sukcinilbenzoat-KoA ligaza (EC 6.2.1.26, o-sukcinilbenzoil-koenzim A sintetaza, o-sukcinilbenzoat:KoA ligaza (formira AMP)) je enzim sa sistematskim imenom 2-sukcinilbenzoat:KoA ligaza (formira AMP).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + 2-sukcinilbenzoat + KoA

\rightleftharpoons

AMP + difosfat + 4-(2-karboksifenil)-4-oksobutanoil-KoA

Reference

^ Heide, L., Arendt, S. and Leistner, E. (1982). „Enzymatic-synthesis, characterization, and metabolism of the coenzyme-A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K₂) biosynthesis”. J. Biol. Chem. 257: 7396—7400. PMID 7045104.
^ Kolkmann, R. & Leistner, E. (1987). „4-(2′-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K₂ (menaquinone) biosynthesis”. Z. Naturforsch. C: Sci. 42: 1207—1214. PMID 2966501.
^ Meganathan, R. & Bentley, R. (1979). „Menaquinone (vitamin K₂) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes”. J. Bacteriol. 140: 92—98. PMID 500558.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

O-succinylbenzoate---CoA+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Heide, L., Arendt, S. and Leistner, E. (1982). „Enzymatic-synthesis, characterization, and metabolism of the coenzyme-A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K₂) biosynthesis”. J. Biol. Chem. 257: 7396—7400. PMID 7045104.

[2] Kolkmann, R. & Leistner, E. (1987). „4-(2′-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K₂ (menaquinone) biosynthesis”. Z. Naturforsch. C: Sci. 42: 1207—1214. PMID 2966501.

[3] Meganathan, R. & Bentley, R. (1979). „Menaquinone (vitamin K₂) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes”. J. Bacteriol. 140: 92—98. PMID 500558.

[1]

[2]

[3]

п р у Enzimi: CO CS i CN ligaza (EC 6.1-6.3)
6.1: Ugljenik-kiseonik	Aminoacil tRNK sintetaza Alanin Arginin Asparagin Aspartat Cistein D-alanin-poli(fosforibitol) ligaza Glutamat Glutamin Glicin Histidin Izoleucin Leucin Lizin Metionin Fenilalanin Prolin Serin Treonin Triptofan Tirozin Valin
6.2: Ugljenik-sumpor	Sukcinil koenzim A sintetaza Acetil-KoA sintetaza Dugolančana-masna-kiselna-KoA ligaza
6.3: Ugljenik-azot	Glutamin sintetaza Ubikvitinska ligaza Kulin Von Hipel–Lindau tumor supresor UBE3A Mdm2 Kompleks promovisanja anafaze UBR1 Glutationska sintetaza CTP sintaza Adenilosukcinatna sintaza Argininosukcinatna sintaza Holokarboksilazna sintaza GMP sintaza Asparagin sintaza Karbamoil fosfat sintaza I II Glutamat-cisteinska ligaza

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6