Panteteinska hidrolaza

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Panteteinska hidrolaza
EC broj
CAS broj 56093-18-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Panteteinska hidrolaza (EC, panteteinaza, vanin, vanin-1) je enzim sa sistematskim imenom (R)-pantetein amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

(R)-pantetein + H2O (R)-pantotenat + 2-aminoetantiol

Ovaj enzim hidrolizuje jednu od amidnih veza panteteina.


  1. Duprè, S. and Cavallini, D. (1979). „Purification and properties of pantetheinase from horse kidney”. Methods Enzymol. 62: 262—267. PMID 440106. 
  2. Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D. (1984). „Continuous spectrophotometric assay of pantetheinase activity”. Anal. Biochem. 142: 175—181. PMID 6549111. 
  3. Maras, B., Barra, D., Duprè, S. and Pitari, G. (1999). „Is pantetheinase the actual identity of mouse and human vanin-1 proteins?”. FEBS Lett. 461: 149—152. PMID 10567687. 
  4. Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P. (1996). „Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing”. Immunity. 5: 391—405. PMID 8934567. 
  5. Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Duprè, S., Naquet, P. and Galland, F. (2000). „Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice”. FEBS Lett. 483: 149—154. PMID 11042271. 
  6. Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F. (2001). „Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes”. Immunogenetics. 53: 296—306. PMID 11491533. 
  7. Pace, H.C. & Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.—001.9. PMID 11380987. 


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