Polineuridin-aldehidna estaraza
| Polineuridin-aldehidna estaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.78 | ||||||||
| CAS broj | 87041-55-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Polineuridin-aldehidna estaraza (EC 3.1.1.78, polineuridin aldehidna esteraza, PNAE) je enzim sa sistematskim imenom polineuridin aldehid hidrolaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- polineuridin aldehid + H2O 16-epivelozimin + CO2 + metanol
Nakon hidrolize ovog indolnog alkaloidnog estra, karboksilna kiselina se spontano dekarboksiliše dajući sarpaganski skeleton.
Reference[уреди | уреди извор]
- ^ Pfitzner, A. & Stöckigt, J. (1983). „Characterization of polyneuridine aldehyde esterase, a key enzyme in the biosynthesis of sarpagine ajmaline type alkaloids”. Planta Med. 48: 221—227.
- ^ Pfitzner, A. & Stöckigt, J. (1983). „Polyneuridine aldehyde esterase: an unusual specific enzyme involved in the biosynthesis of sarpagine type alkaloids”. J. Chem. Soc. Chem. Commun.: 459—460.
- ^ Dogru, E., Warzecha, H., Seibel, F., Haebel, S., Lottspeich, F. and Stöckigt, J. (2000). „The gene encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosynthesis in plants is an ortholog of the hydrolase super family”. Eur. J. Biochem. 267: 1397—1406. PMID 10691977.
- ^ Mattern-Dogru, E., Ma, X., Hartmann, J., Decker, H. and Stöckigt, J. (2002). „Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis”. Eur. J. Biochem. 269: 2889—2896. PMID 12071952.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Polyneuridine-aldehyde+esterase на US National Library of Medicine Medical Subject Headings (MeSH)
