Polo kinaza

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Polo kinaza
EC broj
CAS broj 149433-93-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Polo kinaza (EC, Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, polo serin-treonin kinaza, polo-like kinaza, polo-like kinaza 1, serin/treonin-specifična Drosophila kinaza polo, STK21) je enzim sa sistematskim imenom ATP:proteinska fosfotransferaza (spindle-pole-zavisna).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + protein \rightleftharpoons ADP + fosfoprotein

Ovaj enzim vezuje pol vretena tokom mitoze i ima važnu ulogu tokom hromozomne segregacije.


  1. Llamazares, S., Moreira, A., Tavares, A., Girdham, C., Spruce, B.A., Gonzalez, C., Karess, R.E., Glover, D.M. and Sunkel, C.E. (1991). „polo encodes a protein kinase homolog required for mitosis in Drosophila”. Gene 5: 2153-2165. PMID 1660828 
  2. Golsteyn, R.M., Mundt, K.E., Fry, A.M. and Nigg, E.A. (1995). „Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function”. J. Cell Biol. 129: 1617-1628. PMID 7790358 
  3. Mulvihill, D.P. and Hyams, J.S. (2002). „Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint. J”. Cell 115: 3575-3586. PMID 12186944 
  4. Ohkura, H. (2003). „Phosphorylation: polo kinase joins an elite club”. Curr. Biol. 13: R912-R914. PMID 14654016 


Spoljašnje veze[уреди]

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