Polo kinaza

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Polo kinaza
Identifikatori
EC broj 2.7.11.21
CAS broj 149433-93-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Polo kinaza (EC 2.7.11.21, Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, polo serin-treonin kinaza, polo-like kinaza, polo-like kinaza 1, serin/treonin-specifična Drosophila kinaza polo, STK21) je enzim sa sistematskim imenom ATP:proteinska fosfotransferaza (spindle-pole-zavisna).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + protein \rightleftharpoons ADP + fosfoprotein

Ovaj enzim vezuje pol vretena tokom mitoze i ima važnu ulogu tokom hromozomne segregacije.

Reference[уреди]

  1. ^ Llamazares, S., Moreira, A., Tavares, A., Girdham, C., Spruce, B.A., Gonzalez, C., Karess, R.E., Glover, D.M. and Sunkel, C.E. (1991). „polo encodes a protein kinase homolog required for mitosis in Drosophila“. Gene 5: 2153-2165. PMID 1660828. 
  2. ^ Golsteyn, R.M., Mundt, K.E., Fry, A.M. and Nigg, E.A. (1995). „Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function“. J. Cell Biol. 129: 1617-1628. PMID 7790358. 
  3. ^ Mulvihill, D.P. and Hyams, J.S. (2002). „Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint. J“. Cell 115: 3575-3586. PMID 12186944. 
  4. ^ Ohkura, H. (2003). „Phosphorylation: polo kinase joins an elite club“. Curr. Biol. 13: R912-R914. PMID 14654016. 

Literatura[уреди]

Spoljašnje veze[уреди]