Prostamid/prostaglandin F2alfa sintaza
| Prostamid/prostaglandin F2alfa sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.20 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prostamid/prostaglandin F2alfa sintaza (EC 1.11.1.20, prostamid/PGF sintaza, prostamidna F sintaza, prostamid/prostaglandinska F sintaza, tPGF sintaza) je enzim sa sistematskim imenom tioredoksin:(5Z,9alfa,11alfa,13E,15S)-9,11-epidioksi-15-hidroksi-prosta-5,13-dienoat oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tioredoksin + (5Z,9alfa,11alfa,13E,15S)-9,11-epidioksi-15-hidroksi-prosta-5,13-dienoat tioredoksin disulfid + (5Z,9alfa,11alfa,13E,15S)-9,11,15-trihidroksiprosta-5,13-dienoat
Ovaj enzim sadrži tioredoksinski tip disulfida kao katalitičku grupu. Prostamid H2 i prostaglandin H2 su najbolji supstrati.
Reference[уреди | уреди извор]
- ^ Moriuchi, H., Koda, N., Okuda-Ashitaka, E., Daiyasu, H., Ogasawara, K., Toh, H., Ito, S., Woodward, D.F. and Watanabe, K. (2008). „Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily”. J. Biol. Chem. 283: 792—801. PMID 18006499.
- ^ Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., Woodward, D.F., Watanabe, K. and Shimada, A. (2011). „Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system”. Brain Res. 1367: 22—32. PMID 20950588.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Prostamide/prostaglandin+F2alpha+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
