Protein-S-izoprenilcistein O-metiltransferaza
| Protein-S-izoprenilcistein O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.100 | ||||||||
| CAS broj | 130731-20-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Protein-S-izoprenilcistein O-metiltransferaza (EC 2.1.1.100, farnezil cistein C-terminalna metiltransferaza, farnezil-proteinska karboksimetiltransferaza, protein C-terminal farnezilcisteinska O-metiltransferaza, farnezilated protein C-terminalna O-metiltransferaza, izoprenilaciona proteinska metiltransferaza, prenilaciona proteinska metiltransferaza, protein S-farnezilcistein C-terminalna metiltransferaza, S-farnezilcisteinska metiltransferaza, prenilcisteinska karboksilmetiltransferaza, prenilcisteinska karboksimetiltransferaza, prenilcisteinska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:protein-C-terminal-S-farnezil-L-cistein O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + protein C-terminalni S-farnezil-L-cistein S-adenozil-L-homocistein + protein C-terminalni S-farnezil-L-cistein metil estar
C-terminalni S-geranilgeranilcistein i S-geranilcistein ostaci se takođe metilišu, mada sporije.
Reference[уреди | уреди извор]
- ^ Clarke, S., Vogel, J.P., Deschenes, R.J. and Stock, J. (1988). „Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases”. Proc. Natl. Acad. Sci. USA. 85: 4643—4647. PMID 3290900.
- ^ Ota, I.M. & Clarke, S. (1989). „Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues”. J. Biol. Chem. 264: 12879—12884. PMID 2753892.
- ^ Stephenson, R.C. & Clarke, S. (1990). „Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate”. J. Biol. Chem. 265: 16248—16254. PMID 2398053.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Protein-S-isoprenylcysteine+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
