Protein geranilgeraniltransferaza tip II
| Protein geranilgeraniltransferaza tip II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.60 | ||||||||
| CAS broj | 135371-29-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Protein geranilgeraniltransferaza tip II (EC 2.5.1.60, GGTaseII, Rab geranilgeraniltransferaza, RabGGTaze, geranilgeranil-difosfat,geranilgeranil-difosfat:protein-cistein geraniltransferaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:protein-cistein geraniltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat + protein-cistein S-geranilgeranil-protein + difosfat
Ovaj enzim zajedno sa proteinskom farneziltransferazom (EC 2.5.1.58) i proteinskom geranilgeraniltransferazom tip I (EC 2.5.1.59) sačinjava proteinsku preniltransferaznu familiju enzima.
Reference[уреди | уреди извор]
- ^ Casey, P.J. & Seabra, M.C. (1996). „Protein prenyltransferases”. J. Biol. Chem. 271: 5289—5292. PMID 8621375.
- ^ Wilson, A.L., Erdman, R.A., Castellano, F. and Maltese, W.A. (1998). „Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases”. Biochem. J. 333: 497—504. PMID 9677305.
- ^ Zhang, H., Seabra, M.C. and Deisenhofer, J. (2000). „Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution”. Structure. 8: 241—251. PMID 10745007.
- ^ Thomä, N.H., Niculae, A., Goody, R.S. and Alexandrov, K. (2001). „Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate”. J. Biol. Chem. 276: 48631—48636. PMID 11591706.
- ^ Rak, A., Niculae, A., Kalinin, A., Thomä, N.H., Sidorovitch, V., Goody, R.S. and Alexandrov, K. (2002). „In vitro assembly, purification, and crystallization of the Rab geranylgeranyl transferase:substrate complex”. Protein Expr. Purif. 25: 23—30. PMID 12071695.
- ^ Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118.
Литература[уреди | уреди извор]
- Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118.
Spoljašnje veze[уреди | уреди извор]
- Protein+geranylgeranyltransferase+type+II на US National Library of Medicine Medical Subject Headings (MeSH)
