Romboidna proteaza

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Romboidna proteaza
EC broj
CAS broj 713145-02-9
Baze podataka
IntEnz IntEnz pregled
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

Romboidna proteaza (EC je enzim.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje tip-1 transmembranskog domena koristeći katalitički par koji se sastoji od serina i histidina koji pripadaju različitim transmembranskim domenima

Ova endopeptidaza je membranski protein koji ima više prolaza kroz membranu.


  1. Urban, S. & Wolfe, M.S. (2005). „Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity”. Proc. Natl. Acad. Sci. USA. 102: 1883—1888. PMID 15684070. 
  2. Brossier, F., Jewett, T.J., Sibley, L.D. and Urban, S. (2005). „A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma”. Proc. Natl. Acad. Sci. USA. 102: 4146—4151. PMID 15753289. 
  3. Herlan, M., Bornhovd, C., Hell, K., Neupert, W. and Reichert, A.S. (2004). „Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor”. J. Cell Biol. 165: 167—173. PMID 15096522. 
  4. Pascall, J.C. and Brown, K.D. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL (2004). „2”. Biochem. Biophys. Res. Commun. 317: 244—252. PMID 15047175. 
  5. Sik, A., Passer, B.J., Koonin, E.V. and Pellegrini, L. (2004). „Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pβ, a nuclear-targeted peptide”. J. Biol. Chem. 279: 15323—15329. PMID 14732705. 
  6. Urban, S. & Freeman, M. (2003). „Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol”. Cell. 11: 1425—1434. PMID 12820957. 
  7. Herlan, M., Vogel, F., Bornhovd, C., Neupert, W. and Reichert, A.S. (2003). „Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA”. J. Biol. Chem. 278: 27781—27788. PMID 12707284. 
  8. McQuibban, G.A., Saurya, S. and Freeman, M. (2003). „Mitochondrial membrane remodelling regulated by a conserved rhomboid protease”. Nature. 423: 537—541. PMID 12774122. 
  9. Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C. and Pellegrini, L. (2003). „The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers”. Genome Biol. 4: R19—R19. PMID 12620104. 
  10. Urban, S. & Freeman, M. (2002). „Intramembrane proteolysis controls diverse signalling pathways throughout evolution”. Curr. Opin. Genet. Dev. 12: 512—518. PMID 12200155. 
  11. Urban, S., Schlieper, D. and Freeman, M. (2002). „Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids”. Curr. Biol. 12: 1507—1512. PMID 12225666. 
  12. Urban, S., Lee, J.R. and Freeman, M. (2002). „A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF-like ligands”. EMBO J. 21: 4277—4286. PMID 12169630. 
  13. Urban, S., Lee, J.R. and Freeman, M. (2001). „Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases”. Cell. 107: 173—182. PMID 11672525. 
  14. Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M. and Freeman, M. (2005). „Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases”. EMBO J. 24: 464—472. PMID 15616571. 
  15. Wang, Y., Zhang, Y. and Ha, Y. (2006). „Crystal structure of a rhomboid family intramembrane protease”. Nature. 444: 179—180. PMID 17051161. 


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