Romboidna proteaza

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Romboidna proteaza
Identifikatori
EC broj 3.4.21.105
CAS broj 713145-02-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Romboidna proteaza (EC 3.4.21.105) je enzim.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje tip-1 transmembranskog domena koristeći katalitički par koji se sastoji od serina i histidina koji pripadaju različitim transmembranskim domenima

Ova endopeptidaza je membranski protein koji ima više prolaza kroz membranu.

Reference[уреди]

  1. Urban, S. and Wolfe, M.S. (2005). „Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity”. Proc. Natl. Acad. Sci. USA 102: 1883-1888. PMID 15684070. 
  2. Brossier, F., Jewett, T.J., Sibley, L.D. and Urban, S. (2005). „A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma”. Proc. Natl. Acad. Sci. USA 102: 4146-4151. PMID 15753289. 
  3. Herlan, M., Bornhovd, C., Hell, K., Neupert, W. and Reichert, A.S. (2004). „Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor”. J. Cell Biol. 165: 167-173. PMID 15096522. 
  4. Pascall, J.C. and Brown, K.D. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL (2004). „2”. Biochem. Biophys. Res. Commun. 317: 244-252. PMID 15047175. 
  5. Sik, A., Passer, B.J., Koonin, E.V. and Pellegrini, L. (2004). „Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pβ, a nuclear-targeted peptide”. J. Biol. Chem. 279: 15323-15329. PMID 14732705. 
  6. Urban, S. and Freeman, M. (2003). „Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol”. Cell 11: 1425-1434. PMID 12820957. 
  7. Herlan, M., Vogel, F., Bornhovd, C., Neupert, W. and Reichert, A.S. (2003). „Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA”. J. Biol. Chem. 278: 27781-27788. PMID 12707284. 
  8. McQuibban, G.A., Saurya, S. and Freeman, M. (2003). „Mitochondrial membrane remodelling regulated by a conserved rhomboid protease”. Nature 423: 537-541. PMID 12774122. 
  9. Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C. and Pellegrini, L. (2003). „The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers”. Genome Biol. 4: R19-R19. PMID 12620104. 
  10. Urban, S. and Freeman, M. (2002). „Intramembrane proteolysis controls diverse signalling pathways throughout evolution”. Curr. Opin. Genet. Dev. 12: 512-518. PMID 12200155. 
  11. Urban, S., Schlieper, D. and Freeman, M. (2002). „Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids”. Curr. Biol. 12: 1507-1512. PMID 12225666. 
  12. Urban, S., Lee, J.R. and Freeman, M. (2002). „A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF-like ligands”. EMBO J. 21: 4277-4286. PMID 12169630. 
  13. Urban, S., Lee, J.R. and Freeman, M. (2001). „Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases”. Cell 107: 173-182. PMID 11672525. 
  14. Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M. and Freeman, M. (2005). „Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases”. EMBO J. 24: 464-472. PMID 15616571. 
  15. Wang, Y., Zhang, Y. and Ha, Y. (2006). „Crystal structure of a rhomboid family intramembrane protease”. Nature 444: 179-180. PMID 17051161. 

Literatura[уреди]

Spoljašnje vezе[уреди]