18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza
| 18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.183 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza (EC 2.1.1.183, 18S rRNK dimetilaza Dim1p, Dim1p, ScDim1, m2(6)A dimetilaza, KIDIM1) je enzim sa sistematskim imenom S-adenozil-L-metionin:18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4 S-adenozil-L-metionin + adenin1779/adenin1780 u 18S rRNK 4 S-adenozil-L-homocistein + N6-dimetiladenin1779/N6-dimetiladenin1780 u 18S rRNK
DIM1 učestvuje u pre-rRNK transformacijama.
Reference[уреди | уреди извор]
- ^ Lafontaine, D., Vandenhaute, J. and Tollervey, D. (1995). „The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast”. Genes Dev. 9: 2470—2481. PMID 7590228.
- ^ Lafontaine, D.L., Preiss, T. and Tollervey, D. (1998). „Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis”. Mol. Cell Biol. 18: 2360—2370. PMID 9528805.
- ^ Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. (2009). „Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases”. J. Mol. Biol. 391: 884—893. PMID 19520088.
- ^ Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. (1994). „The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast”. J. Mol. Biol. 241: 492—497. PMID 8064863.
- ^ O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. (2006). „Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution”. RNA. 12: 725—733. PMID 16540698.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
