MCM7

MCM7
Identifikatori
Alijasi	MCM7
Spoljašnji ID	OMIM: 600592 MGI: 1298398 HomoloGene: 4323 GeneCards: MCM7
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	138,170,684 bp
Obrazac RNK izražavanja
	; ;
	More reference expression data
Genska ontologija
Molecular function	• nucleotide binding; • GO:0008026 helicase activity; • GO:0004003 DNA helicase activity; • single-stranded DNA binding; • GO:0001948, GO:0016582 везивање за протеине плазме; • hydrolase activity; • ATP binding; • DNA binding; • DNA replication origin binding; • single-stranded 3'-5' DNA helicase activity;
Cellular component	• мембрана; • Нуклеоплазма; • Хроматин; • MCM complex; • цитосол; • једро; • Једарце;
Biological process	• cellular response to organic substance; • G1 phase; • cellular response to xenobiotic stimulus; • regulation of phosphorylation; • cellular response to DNA damage stimulus; • cellular response to epidermal growth factor stimulus; • DNA replication initiation; • животни циклус ћелије; • cell population proliferation; • DNA unwinding involved in DNA replication; • репликација ДНК; • G1/S transition of mitotic cell cycle; • double-strand break repair via break-induced replication; • pre-replicative complex assembly involved in nuclear cell cycle DNA replication; • DNA strand elongation involved in DNA replication;
	Sources:Amigo / QuickGO
Ortolozi
	4176
	17220
	ENSG00000166508
	ENSMUSG00000029730
	P33993
	Q61881
	NM_001278595; NM_005916; NM_182776
	NM_008568; NM_001356576; NM_001356577
	NP_001265524; NP_005907; NP_877577
	NP_032594; NP_001343505; NP_001343506
	Wikidata
View/Edit Human	View/Edit Mouse

Faktor licenciranja DNK replikacije MCM7 je protein koji je kod ljudi kodiran MCM7 genom.^[4]

Protein kodiran ovim genom je jedan od visoko konzerviranih proteina mini-hromozomskog održavanja (MCM) koji su esencijalni za inicijaciju replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prireplikacionog kompleksa (pre-RC) i može da učestuje u formiranju replikacionih viljuški i regrutovanju drugih proteina vezanih za DNK replikaciju. MCM kompleks se sastoji od ovog proteina i MCM2, dok 4 i 6 proteini poseduju DNK helikaznu aktivnost, i mogu da deluju kao enzimi DNK odmotavanja. Utvrđeno je da je ciklin D1-zavisna kinaza, CDK4, asocirana sa ovim proteinom, i da može da reguliše vezivanje ovog proteina sa proteinom supresije tumora RB1/RB. Poznate su alternativno splajsovane transkriptne varijante koje kodiraju distinktne izoforme.^[5]

Vidi još[уреди | уреди извор]

Održavanje minihromozoma

Interakcije[уреди | уреди извор]

MCM7 formira interakcije sa:

CDC45-srodni protein^[6]^[7]
CDC6,^[6]^[8]
Proteinska kinaza vezana za ćelijski ciklus podele 7,^[6]
DBF4,^[6]
MCM2,^[6]^[9]^[10]^[11]^[12]
MCM3,^[6]^[8]^[9]^[13]
MCM4,^[9]^[10]^[11]^[14]
MCM5,^[6]^[9]^[15]
MCM6,^[6]^[9]^[10]^[11]
MNAT1,^[16]
ORC1L,^[6]
ORC2L,^[6]
ORC3L,^[6]
ORC5L,^[6]
replikacionim proteinom A1,^[6]
Retinoblastoma protein,^[17] i
UBE3A.^[18]

Vidi još[уреди | уреди извор]

Održavanje minihromozoma

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000029730 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication”. Cytogenet Cell Genet. 68 (3-4): 226—30. PMID 7842741. doi:10.1159/000133918.
^ „Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)”.
^ ^а ^б ^в ^г ^д ^ђ ^е ^ж ^з ^и ^ј ^к ^л Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID 12614612. doi:10.1016/s0022-2836(03)00079-2.
^ Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha”. Eur. J. Biochem. 265 (3): 936—43. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x.
^ ^а ^б Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927.
^ ^а ^б ^в ^г ^д Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. 272 (16): 10928—35. PMID 9099751. doi:10.1074/jbc.272.16.10928.
^ ^а ^б ^в Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells. 8 (5): 413—21. PMID 12694531. doi:10.1046/j.1365-2443.2003.00645.x.
^ ^а ^б ^в You Z, Ishimi Y, Masai H, Hanaoka F (2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. 277 (45): 42471—9. PMID 12207017. doi:10.1074/jbc.M205769200.
^ You Z, Komamura Y, Ishimi Y (1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. 19 (12): 8003—15. PMC 84885 . PMID 10567526.
^ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (2002). „Nuclear organization of DNA replication initiation proteins in mammalian cells”. J. Biol. Chem. 277 (12): 10354—61. PMID 11779870. doi:10.1074/jbc.M111398200.
^ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115.
^ DaFonseca CJ, Shu F, Zhang JJ (2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034—9. PMC 30602 . PMID 11248027. doi:10.1073/pnas.061487598.
^ Wang Y, Xu F, Hall FL (2000). „The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor”. FEBS Lett. 484 (1): 17—21. PMID 11056214. doi:10.1016/s0014-5793(00)02117-7.
^ Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654 . PMID 9566894. doi:10.1128/mcb.18.5.2748.
^ Kühne C, Banks L (1998). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box”. J. Biol. Chem. 273 (51): 34302—9. PMID 9852095. doi:10.1074/jbc.273.51.34302.

Literatura[уреди | уреди извор]

Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle.”. Biochem. Biophys. Res. Commun. 177 (1): 395—400. PMID 1710453. doi:10.1016/0006-291X(91)91996-P.
Musahl C, Schulte D, Burkhart R, Knippers R (1995). „A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.”. Eur. J. Biochem. 230 (3): 1096—101. PMID 7601140. doi:10.1111/j.1432-1033.1995.tb20660.x.
Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.”. Cytogenet. Cell Genet. 65 (4): 276—7. PMID 8258304. doi:10.1159/000133647.
Hu B, Burkhart R, Schulte D, Musahl C, Knippers R (1994). „The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.”. Nucleic Acids Res. 21 (23): 5289—93. PMC 310560 . PMID 8265339. doi:10.1093/nar/21.23.5289-a.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1996). „hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase.”. J. Biol. Chem. 271 (8): 4349—54. PMID 8626784. doi:10.1074/jbc.271.8.4349.
Schulte D, Richter A, Burkhart R, Musahl C, Knippers R (1996). „Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.”. Eur. J. Biochem. 235 (1-2): 144—51. PMID 8631321. doi:10.1111/j.1432-1033.1996.00144.x.
Kiyono T, Fujita M, Hayashi Y, Ishibashi M (1996). „Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family.”. Biochim. Biophys. Acta. 1307 (1): 31—4. PMID 8652665. doi:10.1016/0167-4781(96)00057-7.
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3.”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.”. J. Biol. Chem. 272 (16): 10928—35. PMID 9099751. doi:10.1074/jbc.272.16.10928.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Hiraiwa A, Fujita M, Nagasaka T, Adachi A, Ohashi M, Ishibashi M (1997). „Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth.”. Int. J. Cancer. 74 (2): 180—4. PMID 9133452. doi:10.1002/(SICI)1097-0215(19970422)74:2<180::AID-IJC7>3.0.CO;2-V.
Ishimi Y (1997). „A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.”. J. Biol. Chem. 272 (39): 24508—13. PMID 9305914. doi:10.1074/jbc.272.39.24508.
Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654 . PMID 9566894. doi:10.1128/mcb.18.5.2748.
Suzuki S, Adachi A, Hiraiwa A, Ohashi M, Ishibashi M, Kiyono T (1998). „Cloning and characterization of human MCM7 promoter.”. Gene. 216 (1): 85—91. PMID 9714754. doi:10.1016/S0378-1119(98)00323-0.
Kühne C, Banks L (1999). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box.”. J. Biol. Chem. 273 (51): 34302—9. PMID 9852095. doi:10.1074/jbc.273.51.34302.
Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927.
Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N (1999). „Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.”. Clin. Cancer Res. 5 (8): 2121—32. PMID 10473096.
Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.”. Eur. J. Biochem. 265 (3): 936—43. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000029730 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7842741-4] Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication”. Cytogenet Cell Genet. 68 (3-4): 226—30. PMID 7842741. doi:10.1159/000133918.

[entrez-5] „Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)”.

[pmid12614612-6] а ^б ^в ^г ^д ^ђ ^е ^ж ^з ^и ^ј ^к ^л Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID 12614612. doi:10.1016/s0022-2836(03)00079-2.

[pmid10518787-7] Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha”. Eur. J. Biochem. 265 (3): 936—43. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x.

[pmid10464337-8] а ^б Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. 274 (36): 25927—32. PMID 10464337. doi:10.1074/jbc.274.36.25927.

[pmid9099751-9] а ^б ^в ^г ^д Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. 272 (16): 10928—35. PMID 9099751. doi:10.1074/jbc.272.16.10928.

[pmid12694531-10] а ^б ^в Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells. 8 (5): 413—21. PMID 12694531. doi:10.1046/j.1365-2443.2003.00645.x.

[pmid12207017-11] а ^б ^в You Z, Ishimi Y, Masai H, Hanaoka F (2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. 277 (45): 42471—9. PMID 12207017. doi:10.1074/jbc.M205769200.

[pmid10567526-12] You Z, Komamura Y, Ishimi Y (1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. 19 (12): 8003—15. PMC 84885 . PMID 10567526.

[pmid11779870-13] Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (2002). „Nuclear organization of DNA replication initiation proteins in mammalian cells”. J. Biol. Chem. 277 (12): 10354—61. PMID 11779870. doi:10.1074/jbc.M111398200.

[pmid8798650-14] Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID 8798650. doi:10.1074/jbc.271.39.24115.

[pmid11248027-15] DaFonseca CJ, Shu F, Zhang JJ (2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034—9. PMC 30602 . PMID 11248027. doi:10.1073/pnas.061487598.

[pmid11056214-16] Wang Y, Xu F, Hall FL (2000). „The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor”. FEBS Lett. 484 (1): 17—21. PMID 11056214. doi:10.1016/s0014-5793(00)02117-7.

[pmid9566894-17] Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654 . PMID 9566894. doi:10.1128/mcb.18.5.2748.

[pmid9852095-18] Kühne C, Banks L (1998). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box”. J. Biol. Chem. 273 (51): 34302—9. PMID 9852095. doi:10.1074/jbc.273.51.34302.

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