N6-ciklopentiladenozin
Из Википедије, слободне енциклопедије
| N6-ciklopentil adenozin | |
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| IUPAC ime |
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| Identifikacija | |
| CAS registarski broj | 41552-82-3 |
| PubHem | 657378 |
| SMILES |
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| Svojstva | |
| Molekulska formula | C15H21N5O4 |
| Molarna masa | 335.36 g mol−1 |
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala |
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| Infobox references | |
N6-ciklopentiladenozin (CPA) je lek koji deluje kao selektivni agonist adenozinskog A1 receptora.[1] On uglavnom ima kardiovaskularno dejstva sa samo suptilnim izmenama ponašanja.[2] CPA je u širokoj upotrebi u naučnim istraživanjima adenozinskog receptora i korišten je za razvoj velike familije derivata.[3][4][5][6][7]
Reference [уреди]
- ^ Williams M, Braunwalder A, Erickson TJ (February 1986). „Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue“. Naunyn-Schmiedeberg's Archives of Pharmacology 332 (2): 179–83. DOI:10.1007/BF00511410. PMID 3703020.
- ^ Coffin VL, Spealman RD (April 1987). „Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys“. The Journal of Pharmacology and Experimental Therapeutics 241 (1): 76–83. PMID 3572798.
- ^ Zablocki JA, Wu L, Shryock J, Belardinelli L (2004). „Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF)“. Current Topics in Medicinal Chemistry 4 (8): 839–54. DOI:10.2174/1568026043450998. PMID 15078215.
- ^ Hutchinson SA, Scammells PJ (2004). „A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential“. Current Pharmaceutical Design 10 (17): 2021–39. DOI:10.2174/1381612043384204. PMID 15279543.
- ^ Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J (January 2007). „N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists“. Bioorganic & Medicinal Chemistry Letters 17 (1): 161–6. DOI:10.1016/j.bmcl.2006.09.065. PMID 17045477.
- ^ Elzein E, Zablocki J (December 2008). „A1 adenosine receptor agonists and their potential therapeutic applications“. Expert Opinion on Investigational Drugs 17 (12): 1901–10. DOI:10.1517/13543780802497284. PMID 19012505.
- ^ Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, Klotz KN, Marabese I, Luongo L, Maione S, Grifantini M (April 2009). „N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice“. Journal of Medicinal Chemistry 52 (8): 2393–406. DOI:10.1021/jm801456g. PMID 19317449.
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