ЦГМП-зависна протеинска киназа
| CGMP-zavisna proteinska kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.11.12 | ||||||||
| CAS broj | 141588-27-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
CGMP-zavisna proteinska kinaza (EC 2.7.11.12, 3':5'-ciklična GMP-zavisna proteinska kinaza, cGMP-zavisna proteinska kinaza Ibeta, guanozin 3':5'-ciklični monofosfat-zavisna proteinska kinaza, PKG, PKG 1alfa, PKG 1beta, PKG II, STK23) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (cGMP-zavisni).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + protein ADP + fosfoprotein
CGMP je neophodan za aktivaciju enzima.
Reference
[уреди | уреди извор]- ^ Gill, G.N., Holdy, K.E., Walton, G.M. and Kanstein, C.B. (1976). „Purification and characterization of 3′:5′-cyclic GMP-dependent protein kinase”. Proc. Natl. Acad. Sci. USA. 73: 3918—3922. PMID 186778.
- ^ Murthy, K.S. (2004). „Modulation of soluble guanylate cyclase activity by phosphorylation”. Neurochem. Int. 45: 845—851. PMID 15312978.
- ^ Richie-Jannetta, R., Francis, S.H. and Corbin, J.D. (2003). „Dimerization of cGMP-dependent protein kinase Iβ is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function”. J. Biol. Chem. 278: 50070—50079. PMID 12933804.
- ^ Zhao, J., Trewhella, J., Corbin, J., Francis, S., Mitchell, R., Brushia, R. and Walsh, D. (1997). „Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution”. J. Biol. Chem. 272: 31929—31936. PMID 9395542.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- CGMP-dependent+protein+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
