Дефосфо-(редуктаза киназа) киназа
| Defosfo-(reduktaza kinaza) kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.3 | ||||||||
| CAS broj | 72060-33-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3, AMP-activirana kinaza, AMP-activirana proteinska kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza (fosforilacija), reduktazna kinaza, reduktazna kinaza kinaza, STK30) je enzim sa sistematskim imenom ATP:defosfo-{(hidroksimetilglutaril-KoA reduktaza (NADPH)) kinaza} fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + defosfo-{[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza} ADP + {[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}
Ovaj enzim se aktivira AMP-om i specifičan je za svoj supstrat.
Reference[уреди | уреди извор]
- ^ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). „Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase”. Proc. Natl. Acad. Sci. USA. 76: 4375—4379. PMID 291971.
- ^ Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268—1277. PMID 666819.
- ^ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). „Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase”. J. Biol. Chem. 260: 1682—1687. PMID 3155737.
- ^ Clarke, P.R. & Hardie, D.G. (1990). „Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver”. EMBO J. 9: 2439—2446. PMID 2369897.
- ^ Sato, R., Goldstein, J.L. and Brown, M.S. (1993). „Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion”. Proc. Natl. Acad. Sci. USA. 90: 9261—9265. PMID 8415689.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Dephospho-(reductase+kinase)+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
