ЕРББ4

ERBB4
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Identifikatori
Alijasi	ERBB4
Spoljašnji ID	OMIM: 600543 MGI: 104771 HomoloGene: 21084 GeneCards: ERBB4
Genska lokacija (miš)
Hr.	Chromosome 1 (mouse)
Kraj	69,147,218 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • protein homodimerization activity; • epidermal growth factor receptor binding; • kinase activity; • GO:0001948, GO:0016582 везивање за протеине плазме; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • Receptor tirozinska kinaza; • transmembrane signaling receptor activity;
Cellular component	• саставни део мембране; • цитосол; • мембрана; • receptor complex; • ћелијска мембрана; • Нуклеоплазма; • ванћелијска област; • mitochondrial matrix; • basolateral plasma membrane; • митохондрије; • једро; • postsynaptic membrane; • glutamatergic synapse; • GABA-ergic synapse; • integral component of presynaptic membrane; • integral component of postsynaptic density membrane; • цитоплазма; • integral component of plasma membrane; • basal plasma membrane;
Biological process	• mitochondrial fragmentation involved in apoptotic process; • negative regulation of neuron migration; • cell fate commitment; • positive regulation of protein phosphorylation; • regulation of cell migration; • GO:0009373 regulation of transcription, DNA-templated; • olfactory bulb interneuron differentiation; • embryonic pattern specification; • Fosforilacija; • transmembrane receptor protein tyrosine kinase signaling pathway; • central nervous system morphogenesis; • mammary gland alveolus development; • transcription, DNA-templated; • ментални развој; • mammary gland epithelial cell differentiation; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • heart development; • protein phosphorylation; • positive regulation of cardiac muscle cell proliferation; • neural crest cell migration; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of protein localization to cell surface; • protein autophosphorylation; • cardiac muscle tissue regeneration; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • lactation; • cell population proliferation; • cell migration; • GO:0072468 Prenos signala; • negative regulation of cell population proliferation; • GO:0097285 апоптоза; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine autophosphorylation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • regulation of cell motility; • негативно регулисање апоптотичког процеса; • cellular response to epidermal growth factor stimulus; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of protein kinase B signaling; • positive regulation of receptor signaling pathway via JAK-STAT; • synapse assembly; • negative regulation of signal transduction; • диференцијација;
	Sources:Amigo / QuickGO
Ortolozi
	2066
	13869
	ENSG00000178568
	ENSMUSG00000062209
	Q15303
	Q61527
	NM_001042599; NM_005235
	NM_010154
	NP_001036064; NP_005226
	NP_034284
	Wikidata
View/Edit Human	View/Edit Mouse

Receptorska tirozinska proteinska kinaza erbB-4 je enzim koji je kod ljudi kodiran ERBB4 genom.^[4]^[5] Alternativno splajsovane varijante koje kodiraju različite proteinske izoforme su poznate; mada sve nisu izučene.^[6]

Interakcije[уреди | уреди извор]

ERBB4 formira interakcije sa:

Reference[уреди | уреди извор]

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000062209 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (1995). „Localization of the human HER4/erbB-4 gene to chromosome 2”. Oncogene. 10 (6): 1235—7. PMID 7700649.
^ Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (2006). „Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain”. Cell. 127 (1): 185—97. PMID 17018285. doi:10.1016/j.cell.2006.07.037.
^ „Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)”.
^ Garcia RA, Vasudevan K, Buonanno A (2000). „The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses”. Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3596—601. PMC 16285 . PMID 10725395. doi:10.1073/pnas.070042497.
^ Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L (2000). „Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses”. Neuron. 26 (2): 443—55. PMID 10839362. doi:10.1016/S0896-6273(00)81176-9.
^ Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE (2004). „The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone”. The Journal of Cell Biology. 167 (3): 469—78. PMC 2172499 . PMID 15534001. doi:10.1083/jcb.200403155.
^ Schulze WX, Deng L, Mann M (2005). „Phosphotyrosine interactome of the ErbB-receptor kinase family”. Molecular Systems Biology. 1 (1): 2005.0008. PMC 1681463 . PMID 16729043. doi:10.1038/msb4100012.
^ Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M (2004). „Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level”. Experimental Cell Research. 294 (2): 469—79. PMID 15023535. doi:10.1016/j.yexcr.2003.12.002.

Literatura[уреди | уреди извор]

Carpenter G (2003). „ErbB-4: mechanism of action and biology”. Experimental Cell Research. 284 (1): 66—77. PMID 12648466. doi:10.1016/S0014-4827(02)00100-3.
Culouscou JM, Plowman GD, Carlton GW, Green JM, Shoyab M (1993). „Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor”. The Journal of Biological Chemistry. 268 (25): 18407—10. PMID 7689552.
Barbacci EG, Guarino BC, Stroh JG, Singleton DH, Rosnack KJ, Moyer JD, Andrews GC (1995). „The structural basis for the specificity of epidermal growth factor and heregulin binding”. The Journal of Biological Chemistry. 270 (16): 9585—9. PMID 7721889. doi:10.1074/jbc.270.16.9585.
Nagata K, Kohda D, Hatanaka H, Ichikawa S, Matsuda S, Yamamoto T, Suzuki A, Inagaki F (1994). „Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4”. The EMBO Journal. 13 (15): 3517—23. PMC 395255 . PMID 8062828.
Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M (1993). „Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family”. Proceedings of the National Academy of Sciences of the United States of America. 90 (5): 1746—50. PMC 45956 . PMID 8383326. doi:10.1073/pnas.90.5.1746.
Cohen BD, Green JM, Foy L, Fell HP (1996). „HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers”. The Journal of Biological Chemistry. 271 (9): 4813—8. PMID 8617750. doi:10.1074/jbc.271.9.4813.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). „A "double adaptor" method for improved shotgun library construction”. Analytical Biochemistry. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). „Large-scale concatenation cDNA sequencing”. Genome Research. 7 (4): 353—8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Elenius K, Paul S, Allison G, Sun J, Klagsbrun M (1997). „Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation”. The EMBO Journal. 16 (6): 1268—78. PMC 1169725 . PMID 9135143. doi:10.1093/emboj/16.6.1268.
Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (1997). „Ligands for ErbB-family receptors encoded by a neuregulin-like gene”. Nature. 387 (6632): 509—12. PMID 9168114. doi:10.1038/387509a0.
Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (1997). „Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases”. Nature. 387 (6632): 512—6. PMID 9168115. doi:10.1038/387512a0.
Chow NH, Liu HS, Yang HB, Chan SH, Su IJ (1997). „Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study”. Virchows Archiv. 430 (6): 461—6. PMID 9230911. doi:10.1007/s004280050056.
Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (1997). „Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4”. Proceedings of the National Academy of Sciences of the United States of America. 94 (18): 9562—7. PMC 23218 . PMID 9275162. doi:10.1073/pnas.94.18.9562.
Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, Klagsbrun M (1997). „A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester”. The Journal of Biological Chemistry. 272 (42): 26761—8. PMID 9334263. doi:10.1074/jbc.272.42.26761.
Komurasaki T, Toyoda H, Uchida D, Morimoto S (1998). „Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4”. Oncogene. 15 (23): 2841—8. PMID 9419975. doi:10.1038/sj.onc.1201458.
Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ (1998). „Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3”. The Journal of Biological Chemistry. 273 (13): 7717—24. PMID 9516479. doi:10.1074/jbc.273.13.7717.
Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX (1998). „Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis”. The Journal of Biological Chemistry. 273 (19): 11667—74. PMID 9565587. doi:10.1074/jbc.273.19.11667.
Srinivasan R, Poulsom R, Hurst HC, Gullick WJ (1998). „Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types”. The Journal of Pathology. 185 (3): 236—45. PMID 9771476. doi:10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7.
Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (1999). „Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase”. Oncogene. 18 (17): 2681—9. PMID 10348342. doi:10.1038/sj.onc.1202631.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000062209 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7700649-4] Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (1995). „Localization of the human HER4/erbB-4 gene to chromosome 2”. Oncogene. 10 (6): 1235—7. PMID 7700649.

[pmid17018285-5] Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (2006). „Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain”. Cell. 127 (1): 185—97. PMID 17018285. doi:10.1016/j.cell.2006.07.037.

[entrez-6] „Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)”.

[pmid10725395-7] Garcia RA, Vasudevan K, Buonanno A (2000). „The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses”. Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3596—601. PMC 16285 . PMID 10725395. doi:10.1073/pnas.070042497.

[pmid10839362-8] Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L (2000). „Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses”. Neuron. 26 (2): 443—55. PMID 10839362. doi:10.1016/S0896-6273(00)81176-9.

[pmid15534001-9] Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE (2004). „The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone”. The Journal of Cell Biology. 167 (3): 469—78. PMC 2172499 . PMID 15534001. doi:10.1083/jcb.200403155.

[pmid16729043-10] Schulze WX, Deng L, Mann M (2005). „Phosphotyrosine interactome of the ErbB-receptor kinase family”. Molecular Systems Biology. 1 (1): 2005.0008. PMC 1681463 . PMID 16729043. doi:10.1038/msb4100012.

[pmid15023535-11] Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M (2004). „Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level”. Experimental Cell Research. 294 (2): 469—79. PMID 15023535. doi:10.1016/j.yexcr.2003.12.002.

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