Receptor insulinu sličnog faktora rasta 1
| Receptor insulinu sličnog faktora rasta 1 | |||||||||||
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| Dostupne strukture | |||||||||||
| 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU | |||||||||||
| Identifikatori | |||||||||||
| Simboli | IGF1R; CD221; IGFIR; IGFR; JTK13 | ||||||||||
| Vanjski ID | OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3480 | 16001 | |||||||||
| Ensembl | ENSG00000140443 | ENSMUSG00000005533 | |||||||||
| UniProt | P08069 | Q60751 | |||||||||
| RefSeq (mRNA) | NM_000875.3 | NM_010513.2 | |||||||||
| RefSeq (protein) | NP_000866.1 | NP_034643.2 | |||||||||
| Lokacija (UCSC) |
Chr 15: 99.19 - 99.51 Mb |
Chr 7: 67.95 - 68.23 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora. Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.
Interakcije[уреди | уреди извор]
Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,[1] PTPN11,[2][3] SOCS2,[4] GRB10,[5][6][7][8] PIK3R3,[9] C-src tirosinska kinaza,[10] EHD1,[11] Cbl genom,[12] RAS p21 proteinskim aktivatorom 1,[3] IRS1,[2][6][13] ARHGEF12,[14] YWHAE,[15] Mdm2,[12] SHC1[6][13][16] i NEDD4.[5][12]
Regulacija[уреди | уреди извор]
Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.[17]
Vidi još[уреди | уреди извор]
- Insulinski receptor
- Linzitinib, inhibitor IGF-1 u kliničkim ispitivanje za tretman kancera
References[уреди | уреди извор]
- ^ Dey, B R; Furlanetto R W; Nissley P (2000). „Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochem. Biophys. Res. Commun. UNITED STATES. 278 (1): 38—43. ISSN 0006-291X. PMID 11071852. doi:10.1006/bbrc.2000.3762.
- ^ а б Mañes, S; Mira E; et al. (1999). „Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Mol. Cell. Biol. UNITED STATES. 19 (4): 3125—35. ISSN 0270-7306. PMC 84106
. PMID 10082579. Недостаје |last2=у Authors list (помоћ) - ^ а б Seely, B L; Reichart D R; et al. (1995). „Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. J. Biol. Chem. UNITED STATES. 270 (32): 19151—7. ISSN 0021-9258. PMID 7642582. doi:10.1074/jbc.270.32.19151. Недостаје
|last2=у Authors list (помоћ) - ^ Dey, B R; Spence S L; et al. (1998). „Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. J. Biol. Chem. UNITED STATES. 273 (37): 24095—101. ISSN 0021-9258. PMID 9727029. doi:10.1074/jbc.273.37.24095.
- ^ а б Vecchione, Andrea; Marchese Adriano; et al. (2003). „The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol. Cell. Biol. United States. 23 (9): 3363—72. ISSN 0270-7306. PMC 153198 . PMID 12697834. doi:10.1128/MCB.23.9.3363-3372.2003.
- ^ а б в Dey, B R; Frick K; et al. (1996). „Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol. Endocrinol. UNITED STATES. 10 (6): 631—41. ISSN 0888-8809. PMID 8776723. doi:10.1210/me.10.6.631.
- ^ He, W; Rose D W; et al. (1998). „Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. UNITED STATES. 273 (12): 6860—7. ISSN 0021-9258. PMID 9506989. doi:10.1074/jbc.273.12.6860.
- ^ Morrione, A; Valentinis B; et al. (1996). „Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. UNITED STATES. 56 (14): 3165—7. ISSN 0008-5472. PMID 8764099.
- ^ Mothe, I; Delahaye L; et al. (1997). „Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Mol. Endocrinol. UNITED STATES. 11 (13): 1911—23. ISSN 0888-8809. PMID 9415396. doi:10.1210/me.11.13.1911.
- ^ Arbet-Engels, C; Tartare-Deckert S; Eckhart W (1999). „C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. J. Biol. Chem. UNITED STATES. 274 (9): 5422—8. ISSN 0021-9258. PMID 10026153. doi:10.1074/jbc.274.9.5422.
- ^ Rotem-Yehudar, R; Galperin E; Horowitz M (2001). „Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. J. Biol. Chem. United States. 276 (35): 33054—60. ISSN 0021-9258. PMID 11423532. doi:10.1074/jbc.M009913200.
- ^ а б в Sehat, Bita; Andersson Sandra; et al. (2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. United States. 68 (14): 5669—77. PMID 18632619. doi:10.1158/0008-5472.CAN-07-6364. Недостаје
|last2=у Authors list (помоћ) - ^ а б Tartare-Deckert, S; Sawka-Verhelle D; et al. (1995). „Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. J. Biol. Chem. UNITED STATES. 270 (40): 23456—60. ISSN 0021-9258. PMID 7559507. doi:10.1074/jbc.270.40.23456.
- ^ Taya, S; Inagaki N; et al. (2001). „Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. J. Cell Biol. United States. 155 (5): 809—20. ISSN 0021-9525. PMC 2150867 . PMID 11724822. doi:10.1083/jcb.200106139.
- ^ Craparo, A; Freund R; Gustafson T A (1997). „14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. J. Biol. Chem. UNITED STATES. 272 (17): 11663—9. ISSN 0021-9258. PMID 9111084. doi:10.1074/jbc.272.17.11663.
- ^ Santen, R J; Song R X; et al. (2005). „Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocr. Relat. Cancer. 12. England. Suppl 1 (Supplement_1): S61—73. ISSN 1351-0088. PMID 16113100. doi:10.1677/erc.1.01018.
- ^ Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang; Zhou, Xiaofeng (2010). „MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. Biochemical Journal. 432 (1): 199—205. PMID 20819078. doi:10.1042/BJ20100859.
Literatura[уреди | уреди извор]
- Benito M, Valverde AM, Lorenzo M (1996). „IGF-I: a mitogen also involved in differentiation processes in mammalian cells.”. Int. J. Biochem. Cell Biol. 28 (5): 499—510. PMID 8697095. doi:10.1016/1357-2725(95)00168-9.
- Butler AA; Yakar S; Gewolb IH; et al. (1999). „Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.”. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 121 (1): 19—26. PMID 9972281. doi:10.1016/S0305-0491(98)10106-2.
- Zhang X, Yee D (2001). „Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.”. Breast Cancer Res. 2 (3): 170—5. PMC 138771 . PMID 11250706. doi:10.1186/bcr50.
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Spoljašnje veze[уреди | уреди извор]
- IGF-1+Receptor на US National Library of Medicine Medical Subject Headings (MeSH)
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