ERBB4

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ERBB4
Protein ERBB4 PDB 2ahx.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifikatori
AlijasiERBB4
Spoljašnji IDOMIM: 600543 HomoloGene: 21084 GeneCards: ERBB4
Obrazac RNK izražavanja
PBB GE ERBB4 206794 at fs.png
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042599
NM_005235

n/a

RefSeq (protein)

NP_001036064
NP_005226

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Receptorska tirozinska proteinska kinaza erbB-4 je enzim koji je kod ljudi kodiran ERBB4 genom.[2][3] Alternativno splajsovane varijante koje kodiraju različite proteinske izoforme su poznate; mada sve nisu izučene.[4]

Interakcije[уреди]

ERBB4 formira interakcije sa:

Reference[уреди]

  1. ^ „Human PubMed Reference:”. 
  2. ^ Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (1995). „Localization of the human HER4/erbB-4 gene to chromosome 2”. Oncogene. 10 (6): 1235—7. PMID 7700649. 
  3. ^ Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (2006). „Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain”. Cell. 127 (1): 185—97. PMID 17018285. doi:10.1016/j.cell.2006.07.037. 
  4. ^ „Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)”. 
  5. ^ Garcia RA, Vasudevan K, Buonanno A (2000). „The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses”. Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3596—601. PMC 16285Слободан приступ. PMID 10725395. doi:10.1073/pnas.070042497. 
  6. ^ Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L (2000). „Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses”. Neuron. 26 (2): 443—55. PMID 10839362. doi:10.1016/S0896-6273(00)81176-9. 
  7. ^ Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE (2004). „The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone”. The Journal of Cell Biology. 167 (3): 469—78. PMC 2172499Слободан приступ. PMID 15534001. doi:10.1083/jcb.200403155. 
  8. ^ Schulze WX, Deng L, Mann M (2005). „Phosphotyrosine interactome of the ErbB-receptor kinase family”. Molecular Systems Biology. 1 (1): 2005.0008. PMC 1681463Слободан приступ. PMID 16729043. doi:10.1038/msb4100012. 
  9. ^ Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M (2004). „Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level”. Experimental Cell Research. 294 (2): 469—79. PMID 15023535. doi:10.1016/j.yexcr.2003.12.002. 

Literatura[уреди]