RFC3
| Replikacioni faktor C (aktivator 1) 3, 38kDa | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | RFC3; RFC38 | ||||||||||
| Vanjski ID | OMIM: 600405 MGI: 1916513 HomoloGene: 2188 GeneCards: RFC3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5983 | 69263 | |||||||||
| Ensembl | ENSG00000133119 | ENSMUSG00000033970 | |||||||||
| UniProt | P40938 | Q8R323 | |||||||||
| Ref. Sekv. (iRNK) | NM_002915 | NM_027009 | |||||||||
| Ref. Sekv. (protein) | NP_002906 | NP_081285 | |||||||||
| Lokacija (UCSC) |
Chr 13: 34.39 - 34.54 Mb |
Chr 5: 151.64 - 151.65 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Replikacioni faktor C, podjedinica 3 je protein koji je kod ljudi kodiran RFC3 genom[1][2].
Za elongaciju prajmiranog DNK šablona DNK polimeraze delta i DNK polimeraze epsilon neophodni su pomoćni proteini: proliferativni ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 140, 40, 38, 37, i 36 kDa. Ovaj gen kodira 38 kDa podjednicu. Ta podjedinica je esencijalna za interakciju između 140 kDa podjedinice i srži kompleksa koja se sastoji od 36, 37, i 40 kDa podjedinica. Poznate su alternativno splajsovane transcriptne varijante koje kodiraju različite izoforme[2].
Interakcije[uredi | uredi izvor]
RFC3 formira interakcije sa BRD4,[3] CHTF18,[4][5] RFC1,[6][7][8] PCNA[5][9] i RFC4.[6][7]
Reference[uredi | uredi izvor]
- ^ Okumura K; Nogami M; Taguchi H; Dean FB; Chen M; Pan ZQ; Hurwitz J; Shiratori A; Murakami Y; Ozawa K; et al. (jul 1995). „Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23”. Genomics. 25 (1): 274—8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.
- ^ a b „Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa”.
- ^ Maruyama, Tetsuo; Farina Andrea; et al. (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. United States. 22 (18): 6509—20. ISSN 0270-7306. PMC 135621
. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- ^ Bermudez, Vladimir P; Maniwa Yoshimasa; et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (18): 10237—42. ISSN 0027-8424. PMC 193545 . PMID 12930902. doi:10.1073/pnas.1434308100.
- ^ а б Merkle, Carolin J; Karnitz Larry M; et al. (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment”. J. Biol. Chem. United States. 278 (32): 30051—6. ISSN 0021-9258. PMID 12766176. doi:10.1074/jbc.M211591200.
- ^ а б Ellison, V; Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. UNITED STATES. 273 (10): 5979—87. ISSN 0021-9258. PMID 9488738. doi:10.1074/jbc.273.10.5979.
- ^ а б Uhlmann, F; Cai J; et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (13): 6521—6. ISSN 0027-8424. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
- ^ Tomida, Junya; Masuda Yuji; et al. (2008). „DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex”. J. Biol. Chem. United States. 283 (14): 9071—9. ISSN 0021-9258. PMC 2431014 . PMID 18245774. doi:10.1074/jbc.M709835200.
- ^ Ohta, Satoshi; Shiomi Yasushi; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. United States. 277 (43): 40362—7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.
Литература[uredi | uredi izvor]
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1-2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- O'Donnell M; Onrust R; Dean FB; et al. (1993). „Homology in accessory proteins of replicative polymerases--E. coli to humans.”. Nucleic Acids Res. 21 (1): 1—3. PMC 309057 . PMID 8441605. doi:10.1093/nar/21.1.1.
- Uhlmann F; Cai J; Flores-Rozas H; et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
- Uhlmann F; Cai J; Gibbs E; et al. (1997). „Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities.”. J. Biol. Chem. 272 (15): 10058—64. PMID 9092549. doi:10.1074/jbc.272.15.10058.
- Cujec TP; Cho H; Maldonado E; et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.”. Mol. Cell. Biol. 17 (4): 1817—23. PMC 232028 . PMID 9121429.
- Cai J; Gibbs E; Uhlmann F; et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme.”. J. Biol. Chem. 272 (30): 18974—81. PMID 9228079. doi:10.1074/jbc.272.30.18974.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1-2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979.
- Zhang G; Gibbs E; Kelman Z; et al. (1999). „Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869—74. PMC 26703 . PMID 10051561. doi:10.1073/pnas.96.5.1869.
- Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000). „The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.”. J. Biol. Chem. 275 (38): 29767—71. PMID 10884395. doi:10.1074/jbc.M005782200.
- Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). „Purification and characterization of human DNA damage checkpoint Rad complexes.”. Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236—41. PMC 58713 . PMID 11572977. doi:10.1073/pnas.201373498.
- Griffith JD, Lindsey-Boltz LA, Sancar A (2002). „Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.”. J. Biol. Chem. 277 (18): 15233—6. PMID 11907025. doi:10.1074/jbc.C200129200.
- Ohta S; Shiomi Y; Sugimoto K; et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
- Maruyama T; Farina A; Dey A; et al. (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.”. J. Biol. Chem. 278 (32): 30051—6. PMID 12766176. doi:10.1074/jbc.M211591200.
- Bermudez VP; Maniwa Y; Tappin I; et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.”. Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237—42. PMC 193545 . PMID 12930902. doi:10.1073/pnas.1434308100.
- Zou L, Liu D, Elledge SJ (2004). „Replication protein A-mediated recruitment and activation of Rad17 complexes.”. Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13827—32. PMC 283506 . PMID 14605214. doi:10.1073/pnas.2336100100.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.