RFC1

RFC1
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 2EBU, 2K6G, 2K7F
Identifikatori
Alijasi	RFC1
Spoljašnji ID	OMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1
Genska lokacija (miš) Hr. Chromosome 5 (mouse) Band 5 C3.1|5 33.61 cM Start 65,419,193 bp Kraj 65,493,013 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • nucleotide binding • GO:0001948, GO:0016582 везивање за протеине плазме • GO:0010577 enzyme activator activity • ATP binding • DNA clamp loader activity • DNA binding • sequence-specific DNA binding • double-stranded DNA binding • protein domain specific binding • DNA clamp unloader activity Cellular component • Нуклеоплазма • extracellular exosome • Replikacioni faktor C • једро • Једарце • цитоплазма • Elg1 RFC-like complex • GO:0009327 макромолекуларни комплекс Biological process • DNA-dependent DNA replication • nucleotide-excision repair, DNA gap filling • GO:0009373 regulation of transcription, DNA-templated • telomere maintenance via telomerase • error-free translesion synthesis • transcription, DNA-templated • error-prone translesion synthesis • репликација ДНК • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • GO:0100026 поправка ДНК • nucleotide-excision repair, DNA incision, 5'-to lesion • GO:0048554 positive regulation of catalytic activity • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • telomere maintenance via semi-conservative replication • DNA clamp unloading Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	5981	19687
Ensembl	ENSG00000035928	ENSMUSG00000029191
UniProt	P35251	P35601
RefSeq (mRNA)	NM_001204747 NM_002913 NM_001363495 NM_001363496	NM_011258 NM_001347357 NM_001347358
RefSeq (protein)	NP_001191676 NP_002904 NP_001350424 NP_001350425	NP_001334286 NP_001334287 NP_035388
Location (UCSC)	n/a	Chr 5: 65.42 – 65.49 Mb
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Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.

Interakcije

RFC1 formira interakcije sa:

• BRD4,
• HDAC1,
• PCNA,
• RELA and
• RFC3.

Literatura

• Lu Y, Riegel AT (1994). . „The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA”. Gene. 145 (2): 261—5. PMID 7914507. doi:10.1016/0378-1119(94)90017-5. 
• Bunz F, Kobayashi R, Stillman B (1994). . „cDNAs encoding the large subunit of human replication factor C”. Proc. Natl. Acad. Sci. U.S.A.. 90 (23): 11014—8. PMC 47912 . PMID 8248204. doi:10.1073/pnas.90.23.11014. 
• Lu Y, Zeft AS, Riegel AT (1993). . „Cloning and expression of a novel human DNA binding protein, PO-GA”. Biochem. Biophys. Res. Commun.. 193 (2): 779—86. PMID 8512577. doi:10.1006/bbrc.1993.1693. 
• Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). . „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A.. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521. 
• Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). . „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J.. 15 (16): 4423—33. PMC 452166 . PMID 8861969. 
• Uchiumi F, Ohta T, Tanuma S (1997). . „Replication factor C recognizes 5'-phosphate ends of telomeres”. Biochem. Biophys. Res. Commun.. 229 (1): 310—5. PMID 8954124. doi:10.1006/bbrc.1996.1798. 
• Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). . „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem.. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769. 
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). . „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol.. 17 (4): 1817—23. PMC 232028 . PMID 9121429. 
• Ubeda M, Habener JF (1997). . „The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis”. J. Biol. Chem.. 272 (31): 19562—8. PMID 9235961. doi:10.1074/jbc.272.31.19562. 
• Rhéaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sékaly RP, Denis F (1998). . „The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis”. EMBO J.. 16 (21): 6346—54. PMC 1170241 . PMID 9351817. doi:10.1093/emboj/16.21.6346. 
• Ellison V, Stillman B (1998). . „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem.. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979. 
• Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH (1998). . „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res.. 9 (11–12): 629—39. PMID 9563011. 
• Allen BL, Uhlmann F, Gaur LK, Mulder BA, Posey KL, Jones LB, Hardin SH (1998). . „DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C”. Nucleic Acids Res.. 26 (17): 3877—82. PMC 147807 . PMID 9705493. doi:10.1093/nar/26.17.3877. 
• van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). . „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med.. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365. 
• Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000). . „BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes Dev.. 14 (8): 927—39. PMC 316544 . PMID 10783165. doi:10.1101/gad.14.8.927. 
• Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002). . „SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint”. Genes Dev.. 16 (5): 571—82. PMC 155356 . PMID 11877377. doi:10.1101/gad.970702. 
• Anderson LA, Perkins ND (2002). . „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem.. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200. 
• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). . „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem.. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
• Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). . „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol.. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.