RFC1

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RFC1
Protein RFC1 PDB 2EBU.png
Available structures
PDBPretraga ortologa: PDBe RCSB
Identifikatori
AlijasiRFC1
Spoljašnji IDOMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1
Obrazac RNK izražavanja
PBB GE RFC1 208021 s at fs.png

PBB GE RFC1 209085 x at fs.png
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204747
NM_002913
NM_001363495
NM_001363496

NM_011258
NM_001347357
NM_001347358

RefSeq (protein)

NP_001191676
NP_002904
NP_001350424
NP_001350425

NP_001334286
NP_001334287
NP_035388

Location (UCSC)n/aChr 5: 65.26 – 65.34 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.[4][5]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.[5]

Interakcije[уреди | уреди извор]

RFC1 formira interakcije sa:

Reference[уреди | уреди извор]

  1. 1,0 1,1 1,2 GRCm38: Ensembl release 89: ENSMUSG00000029191 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (1994). „Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans”. Mol Cell Biol. 14 (3): 1626—34. PMC 358521Слободан приступ. PMID 8114700. 
  5. 5,0 5,1 „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”. 
  6. 6,0 6,1 Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621Слободан приступ. PMID 12192049. doi:10.1128/mcb.22.18.6509-6520.2002. 
  7. ^ Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200. 
  8. ^ Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166Слободан приступ. PMID 8861969. 
  9. ^ Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769. 
  10. ^ van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365. 
  11. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  12. ^ Anderson LA, Perkins ND (2003). „Regulation of RelA (p65) function by the large subunit of replication factor C”. Mol. Cell. Biol. 23 (2): 721—32. PMC 151544Слободан приступ. PMID 12509469. doi:10.1128/mcb.23.2.721-732.2003. 
  13. ^ Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979. 
  14. ^ Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056Слободан приступ. PMID 8692848. doi:10.1073/pnas.93.13.6521. 
  15. ^ Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T (2008). „DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex”. J. Biol. Chem. 283 (14): 9071—9. PMC 2431014Слободан приступ. PMID 18245774. doi:10.1074/jbc.M709835200. 

Literatura[уреди | уреди извор]