RFC1

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RFC1
Protein RFC1 PDB 2EBU.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifikatori
AlijasiRFC1
Spoljašnji IDHomoloGene: 2187 GeneCards: RFC1
Obrazac RNK izražavanja
PBB GE RFC1 208021 s at fs.png

PBB GE RFC1 209085 x at fs.png
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204747
NM_002913
NM_001363495
NM_001363496

n/a

RefSeq (protein)

NP_001191676
NP_002904
NP_001350424
NP_001350425

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.[2][3]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.[3]

Interakcije[уреди]

RFC1 formira interakcije sa:

Reference[уреди]

  1. ^ „Human PubMed Reference:”. 
  2. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  3. 3,0 3,1 „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”. 
  4. 4,0 4,1 Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  5. ^ Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. doi:10.1074/jbc.M200513200. PMID 12045192. 
  6. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  7. ^ Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. doi:10.1074/jbc.272.3.1769. PMID 8999859. 
  8. ^ van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. doi:10.1007/s001090050365. PMID 10353443. 
  9. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. doi:10.1074/jbc.M206194200. PMID 12171929. 
  10. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  11. ^ Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. doi:10.1074/jbc.273.10.5979. PMID 9488738. 
  12. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  13. ^ Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).

Literatura[уреди]

  • Lu Y, Riegel AT (1994). „The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA”. Gene. 145 (2): 261—5. doi:10.1016/0378-1119(94)90017-5. PMID 7914507. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Lu Y, Zeft AS, Riegel AT (1993). „Cloning and expression of a novel human DNA binding protein, PO-GA”. Biochem. Biophys. Res. Commun. 193 (2): 779—86. doi:10.1006/bbrc.1993.1693. PMID 8512577. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Uchiumi F, Ohta T, Tanuma S (1997). „Replication factor C recognizes 5'-phosphate ends of telomeres”. Biochem. Biophys. Res. Commun. 229 (1): 310—5. doi:10.1006/bbrc.1996.1798. PMID 8954124. 
  • Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. doi:10.1074/jbc.272.3.1769. PMID 8999859. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Ubeda M, Habener JF (1997). „The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis”. J. Biol. Chem. 272 (31): 19562—8. doi:10.1074/jbc.272.31.19562. PMID 9235961. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. doi:10.1074/jbc.273.10.5979. PMID 9488738. 
  • Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629—39. PMID 9563011. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. doi:10.1007/s001090050365. PMID 10353443. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).
  • Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. doi:10.1074/jbc.M200513200. PMID 12045192. 
  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. doi:10.1074/jbc.M206194200. PMID 12171929. 
  • Lua грешка in Модул:Citation/CS1/Utilities at line 55: bad argument #1 to 'message.newRawMessage' (string expected, got nil).