Proliferatini ćelijski nuklearni antigen

Из Википедије, слободне енциклопедије
(преусмерено са Proliferativni ćelijski nuklearni antigen)
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PCNA
1axc tricolor.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifikatori
AlijasiPCNA
Spoljašnji IDOMIM: 176740 HomoloGene: 1945 GeneCards: PCNA
Obrazac RNK izražavanja
PBB GE PCNA 201202 at fs.png
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182649
NM_002592

n/a

RefSeq (protein)

NP_002583
NP_872590

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Proliferativni ćelijski nuklearni antigen (PCNA) je DNK stega koja deluje kao faktor procesivnosti za DNK polimerazu δ u eukariotskim ćelijama i koja je esencijalna za replikaciju. PCNA je homotrimer koji ostvaruje svoju procesivnost putem obuhvatanja DNK, pri čemu ona deluje kao osnova na kojoj se vezuju drugi proteini koji su neophodni za DNK replikaciju, DNK popravku, remodelovanje hromatina i epigenetiku.[2]

Mnogi proteini formiraju interakcije sa dva poznata PCNA-interagujuća motiva: PCNA interagujuća peptidna (PIP) kutija[3] i AlkB homolog 2 PCNA interagujući motiv (APIM).[4] Proteinsko vezivanje za PCNA putem PIP-kutije se uglavnom ostvaruje tokom DNK replikacije, dok su proteini koji se vezuju za PCNA putem APIM prvenstveno važni u kontekstu genotoksičnog stresa.[5]

U responsu na DNK oštećenje, ovaj protein biva ubikvitinisan i učestvuje u putu RAD6 zavisne DNK popravke. Poznate su dve transkriptne varijante koje kodiraju isti protein. Pseudogeni ovog gena su prisutni na hromozomu 4 i na X hromozomu.[6]

Interakcije[уреди]

PCNA formira interakcije sa:

Proteini koji formiraju interakcije sa PCNA preko APIM obuhvataju ljudski AlkB homolog 2, TFIIS-L, TFII-I, Rad51B,[4] XPA,[70] ZRANB3,[71] i FBH1.[72]

Reference[уреди]

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