Enoil-KoA hidrataza 2
Изглед
Enoil-KoA hidrataza 2 | |||||||||
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Identifikatori | |||||||||
EC broj | 4.2.1.119 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enoil-KoA hidrataza 2 (EC 4.2.1.119, 2-enoil-KoA hidrataza 2, AtECH2, ECH2, MaoC, MFE-2, PhaJAc, D-3-hidroksiacil-KoA hidrolijaza, D-specifična 2-trans-enoil-KoA hidrataza) je enzim sa sistematskim imenom (3R)-3-hidroksiacil-KoA hidrolijaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3R)-3-hidroksiacil-KoA (2E)-2-enoil-KoA + H2O
Ovaj enzim katalizuje hidracioni korak tokom peroksisomalne beta-oksidacije.
Reference[уреди | уреди извор]
- ^ Koski, K.M., Haapalainen, A.M., Hiltunen, J.K. and Glumoff, T. (2005). „Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2”. J. Mol. Biol. 345: 1157—1169. PMID 15644212.
- ^ Fukui, T., Shiomi, N. and Doi, Y. (1998). „Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae”. J. Bacteriol. 180: 667—673. PMID 9457873.
- ^ Koski, M.K., Haapalainen, A.M., Hiltunen, J.K. and Glumoff, T. (2003). „Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2”. Acta Crystallogr. D Biol. Crystallogr. 59: 1302—1305. PMID 12832794.
- ^ Hisano, T., Fukui, T., Iwata, T. and Doi, Y. (2001). „Crystallization and preliminary X-ray analysis of (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis”. Acta Crystallogr. D Biol. Crystallogr. 57: 145—147. PMID 11134939.
- ^ Goepfert, S., Hiltunen, J.K. and Poirier, Y. (2006). „Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana”. J. Biol. Chem. 281: 35894—35903. PMID 16982622.
- ^ Engeland, K. & Kindl, H. (1991). „Evidence for a peroxisomal fatty acid β-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA”. Eur. J. Biochem. 200: 171—178. PMID 1879422.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Enoyl-CoA+hydratase+2 на US National Library of Medicine Medical Subject Headings (MeSH)