3-Izopropilmalatna dehidrataza
| 3-Izopropilmalatna dehidrataza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.2.1.33 | ||||||||
| CAS broj | 37290-72-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3-Izopropilmalatna dehidrataza (EC 4.2.1.33, (2R,3S)-3-izopropilmalatna hidrolijaza, beta-izopropilmalatna dehidrataza, izopropilmalatna izomeraza, alfa-izopropilmalatna izomeraza, 3-izopropilmalatna hidrolijaza) je enzim sa sistematskim imenom (2R,3S)-3-izopropilmalat hidrolijaza (formira 2-izopropilmaleat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2R,3S)-3-izopropilmalat (2S)-2-izopropilmalat (sveukupna reakcija)
- (1a) (2R,3S)-3-izopropilmalat 2-izopropilmaleat + H2O
- (1b) 2-izopropilmaleat + H2O (2S)-2-izopropilmalat
Ovaj enzim učestvuje u biosintezi leucina.
Reference[уреди | уреди извор]
- ^ Gross, S.R., Burns, R.O. and Umbarger, H.E. (1963). „The biosynthesis of leucine. II. The enzymic isomerization of β-carboxy-β-hydroxyisocaproate and α-hydroxy-β-carboxyisocaproate”. Biochemistry. 2: 1046—1052. PMID 14087357.
- ^ Calvo, J. (1964). „M., Stevens, C. M., Kalyanpur, M. G., and Umbarger, H. E. The absolute configuration of α-hydroxy-β-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis”. Biochemistry. 3: 2024—2027. PMID 14269331.
- ^ Cole, F.E., Kalyanpur, M. (1973). „G. and Stevens, C. M. Absolute configuration of α-isopropylmalate and the mechanism of its conversion to β-isopropylmalate in the biosynthesis of leucine”. Biochemistry. 12: 3346—3350. PMID 4270046.
- ^ Jang, S. & Imlay, J.A. (2007). „Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes”. J. Biol. Chem. 282: 929—937. PMID 17102132.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 3-isopropylmalate+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)
