GNA13

Guanin nukleotid-vezujući protein (G protein), alfa 13
Guanin nukleotid-vezujući protein (G protein), alfa 13
	PDB prikaz baziran na 1zcb.
Dostupne strukture
	1zcb
Identifikatori
Simboli	GNA13; G13; MGC46138
Vanjski ID	OMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCards: GNA13 Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • aktivnost GTPaze; • aktivnost receptora signalnih proteina; • vezivanje proteina; • GTP vezivanje;
Celularna komponenta	• membrana;
Biološki proces	• obrazovaje krvnih sudova; • in utero embrionski razvoj; • ćelijska motilnost; • prenos signala; • signalni put G-protein spregnutog receptora; • kaskada protein kinaza; • Ro protein signalna transdukcija; • regulacija ćelijskog oblika; • ćelijska diferencijacija; • aktivacija trombocita; • regulacija ćelijske migracije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	10672
Ensembl	ENSG00000120063
UniProt	Q14344
RefSeq (mRNA)	NM_006572
RefSeq (protein)	NP_006563
Lokacija (UCSC)	Chr 17:; 60.44 - 60.48 Mb
PubMed pretraga	[1]

GNA13, Guanin nukleotid-vezujući protein alfa 13 je protein koji je kod ljudi kodiran GNA13 genom.^[1]^[2]

Interactions[уреди | уреди извор]

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1,^[3]^[4] AKAP3,^[5] RIC8A,^[6] Radixin^[7] i ARHGEF12.^[8]^[9]

Reference[уреди | уреди извор]

^ Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (1995). „Expression of GTP-binding protein alpha subunits in human thymocytes”. Mol Cell Biochem. 144 (1): 45—51. PMID 7791744. doi:10.1007/BF00926739.
^ „Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13”.
^ Bhattacharyya, Raja; Wedegaertner Philip B (2003). „Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment”. FEBS Lett. Netherlands. 540 (1-3): 211—6. ISSN 0014-5793. PMID 12681510. doi:10.1016/S0014-5793(03)00267-9.
^ Hart, M J; Jiang X; et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13”. Science. UNITED STATES. 280 (5372): 2112—4. ISSN 0036-8075. PMID 9641916. doi:10.1126/science.280.5372.2112.
^ Niu, J; Vaiskunaite R; et al. (2001). „Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation”. Curr. Biol. England. 11 (21): 1686—90. ISSN 0960-9822. PMID 11696326. doi:10.1016/S0960-9822(01)00530-9.
^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.
^ Vaiskunaite, R; Adarichev V; et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit”. J. Biol. Chem. UNITED STATES. 275 (34): 26206—12. ISSN 0021-9258. PMID 10816569. doi:10.1074/jbc.M001863200.
^ Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.
^ Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100.

Literatura[уреди | уреди извор]

Ruppel KM; Willison D; Kataoka H; Wang A; Zheng YW; Cornelissen I; Liya Yin; Xu SM & Coughlin SR (2005). „Essential role for Galpha 13 in endothelial cells during embryonic development.”. Proc. Natl. Acad. Sci. U.S.A. 102 (22): 8281—8286. PMC 1149452 . PMID 15919816. doi:10.1073/pnas.0503326102.
Downes GB, Gautam N (2000). „The G protein subunit gene families.”. Genomics. 62 (3): 544—52. PMID 10644457. doi:10.1006/geno.1999.5992.
Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). „G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.”. Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504—8. PMC 42977 . PMID 8290554. doi:10.1073/pnas.91.2.504.
Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 . PMID 8552586. doi:10.1073/pnas.93.1.116.
Offermanns S, Hu YH, Simon MI (1996). „Galpha12 and galpha13 are phosphorylated during platelet activation.”. J. Biol. Chem. 271 (42): 26044—8. PMID 8824244. doi:10.1074/jbc.271.42.26044.
Offermanns S, Mancino V, Revel JP, Simon MI (1997). „Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency.”. Science. 275 (5299): 533—6. PMID 8999798. doi:10.1126/science.275.5299.533.
Macrez-Leprêtre N; Kalkbrenner F; Morel JL; et al. (1997). „G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes.”. J. Biol. Chem. 272 (15): 10095—102. PMID 9092554. doi:10.1074/jbc.272.15.10095.
Hart MJ; Jiang X; Kozasa T; et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.”. Science. 280 (5372): 2112—4. PMID 9641916. doi:10.1126/science.280.5372.2112.
Fukuhara S; Murga C; Zohar M; et al. (1999). „A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.”. J. Biol. Chem. 274 (9): 5868—79. PMID 10026210. doi:10.1074/jbc.274.9.5868.
Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). „Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.”. Biochim. Biophys. Acta. 1450 (3): 288—96. PMID 10395940. doi:10.1016/S0167-4889(99)00068-3.
Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351—8. PMID 10488065. doi:10.1074/jbc.274.39.27351.
Brydon L; Roka F; Petit L; et al. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.”. Mol. Endocrinol. 13 (12): 2025—38. PMID 10598579. doi:10.1210/me.13.12.2025.
Bhattacharyya R, Wedegaertner PB (2000). „Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.”. J. Biol. Chem. 275 (20): 14992—9. PMID 10747909. doi:10.1074/jbc.M000415200.
Vaiskunaite R; Adarichev V; Furthmayr H; et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit.”. J. Biol. Chem. 275 (34): 26206—12. PMID 10816569. doi:10.1074/jbc.M001863200.
Shi CS; Sinnarajah S; Cho H; et al. (2000). „G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.”. J. Biol. Chem. 275 (32): 24470—6. PMID 10821841. doi:10.1074/jbc.M908449199.
Ponimaskin E; Behn H; Adarichev V; et al. (2000). „Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.”. FEBS Lett. 478 (1-2): 173—7. PMID 10922491. doi:10.1016/S0014-5793(00)01845-7.
Jin S, Exton JH (2000). „Activation of RhoA by association of Galpha(13) with Dbl.”. Biochem. Biophys. Res. Commun. 277 (3): 718—21. PMID 11062019. doi:10.1006/bbrc.2000.3744.
Fukuhara S, Chikumi H, Gutkind JS (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.”. FEBS Lett. 485 (2-3): 183—8. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.
Meigs TE, Fields TA, McKee DD, Casey PJ (2001). „Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.”. Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519—24. PMC 14619 . PMID 11136230. doi:10.1073/pnas.021350998.

Vidi još[уреди | уреди извор]

G protein

[pmid7791744-1] Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (1995). „Expression of GTP-binding protein alpha subunits in human thymocytes”. Mol Cell Biochem. 144 (1): 45—51. PMID 7791744. doi:10.1007/BF00926739.

[entrez-2] „Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13”.

[pmid12681510-3] Bhattacharyya, Raja; Wedegaertner Philip B (2003). „Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment”. FEBS Lett. Netherlands. 540 (1-3): 211—6. ISSN 0014-5793. PMID 12681510. doi:10.1016/S0014-5793(03)00267-9.

[pmid9641916-4] Hart, M J; Jiang X; et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13”. Science. UNITED STATES. 280 (5372): 2112—4. ISSN 0036-8075. PMID 9641916. doi:10.1126/science.280.5372.2112.

[pmid11696326-5] Niu, J; Vaiskunaite R; et al. (2001). „Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation”. Curr. Biol. England. 11 (21): 1686—90. ISSN 0960-9822. PMID 11696326. doi:10.1016/S0960-9822(01)00530-9.

[pmid12509430-6] Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.

[pmid10816569-7] Vaiskunaite, R; Adarichev V; et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit”. J. Biol. Chem. UNITED STATES. 275 (34): 26206—12. ISSN 0021-9258. PMID 10816569. doi:10.1074/jbc.M001863200.

[pmid11094164-8] Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.

[pmid12515866-9] Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100.

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