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Histonska deacetilaza

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Histonska deacetilaza
Identifikatori
EC broj3.5.1.98
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Histonska deacetilaza (EC 3.5.1.98, HDAC) je enzim sa sistematskim imenom histon amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza N6-acetil-lizinskog ostatka histona čime se formira deacetilisani histon

Ova klasa enzima uklanja acetil grupe sa N6-acetil-lizinskih ostataka na histonu.

  1. ^ Krieger, D.E., Levine, R., Merrifield, R.B., Vidali, G. and Allfrey, V.G. (1974). „Chemical studies of histone acetylation. Substrate specificity of a histone deacetylase from calf thymus nuclei”. J. Biol. Chem. 249: 332—334. PMID 4855628. 
  2. ^ Sanchez del Pino, M.M., Lopez-Rodas, G., Sendra, R. and Tordera, V. (1994). „Properties of the yeast nuclear histone deacetylase”. Biochem. J. 303: 723—729. PMID 7980438. 
  3. ^ Ouaissi, M. & Ouaissi, A. (2006). „Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases”. J. Biomed. Biotechnol. 2006: 13474—13474. PMID 16883049. 
  4. ^ Song, Y.M., Kim, Y.S., Kim, D., Lee, D.S. and Kwon, H.J. (2007). „Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24”. Biochem. Biophys. Res. Commun. 361: 55—61. PMID 17632079. 
  5. ^ Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., Breslow, R. and Pavletich, N.P. (1999). „Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors”. Nature. 401: 188—193. PMID 10490031. 
  6. ^ Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A. and Klein, P.S. (2001). „Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen”. J. Biol. Chem. 276: 36734—36741. PMID 11473107. 
  7. ^ de Ruijter, A.J., van Gennip, A.H., Caron, H.N., Kemp, S. and van Kuilenburg, A.B. (2003). „Histone deacetylases (HDACs): characterization of the classical HDAC family”. Biochem. J. 370: 737—749. PMID 12429021. 

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