Malonil KoA reduktaza (formira malonat semialdehid)
| Malonil KoA reduktaza (formira malonat semialdehid) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.75 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Malonil KoA reduktaza (formira malonat semialdehid) (EC 1.2.1.75, NADP-zavisni malonil KoA reduktaza, malonil KoA reduktaza (NADP)) je enzim sa sistematskim imenom malonat semialdehid:NADP+ oksidoreduktaza (formira malonat semialdehid).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- malonat semialdehid + KoA + NADP+ malonil-KoA + NADPH + H+
Za rad ovog enzima je neohodan Mg2+. On katalizuje redukciju malonil-KoA do malonat semialdehida, što je ključni korak u ciklusu 3-hidroksipropionata i 3-hidroksipropionat/4-hidroksibutirata, putevima autotrofne CO2 fiksacija prisutnim kod nekih zelenih nesumpornih fototrofnih bakterija i nekih termoacidofilnih arheja, respektivno. Enzim iz Sulfolobus tokodaii je prečišćen i utvrđeno je da sadrži jedan RNK molekul za dve podjedinice.
Reference
[уреди | уреди извор]- ^ Strauss, G. & Fuchs, G. (1993). „Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle”. Eur. J. Biochem. 215: 633—643. PMID 8354269.
- ^ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). „A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea”. Science. 318: 1782—1786. PMID 18079405.
- ^ Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., Hugler, M. and Fuchs, G. (2006). „Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp”. J. Bacteriol. 188: 8551—8559. PMID 17041055.
- ^ Hugler, M., Menendez, C., Schagger, H. and Fuchs, G. (2002). „Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation”. J. Bacteriol. 184: 2404—2410. PMID 11948153.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Malonyl+CoA+reductase+(malonate+semialdehyde-forming) на US National Library of Medicine Medical Subject Headings (MeSH)
