Sukcinat-semialdehid dehidrogenaza
| Sukcinat-semialdehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Sukcinat-semialdehid dehidrogenaza dodekamer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.2.1.24 | ||||||||
| CAS broj | 9028-95-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sukcinat-semialdehid dehidrogenaza (EC 1.2.1.24, sukcinat semialdehidna dehidrogenaza (NAD+), sukcinska semialdehidna dehidrogenaza (NAD+), sukcinil semialdehidna dehidrogenaza (NAD+), sukcinat semialdehid:NAD+ oksidoreduktaza) je enzim sa sistematskim imenom sukcinat-semialdehid:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sukcinat semialdehid + NAD+ +H2O sukcinat + NADH + 2 H+
Ovaj enzim učestvuje u degradaciji glutamata i 4-aminobutirata. On je sličan sa EC 1.2.1.79, sukcinatnom-semialdehidnom dehidrogenazom (NADP+), i EC 1.2.1.16, sukcinatnom semialdehidno dehidrogenazom (NAD(P)+), ali je specifičan za NAD+.
Reference
[уреди | уреди извор]- ^ Albers, R.W. & Koval, G.J. (1961). „Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain”. Biochim. Biophys. Acta. 52: 29—35. PMID 13860092.
- ^ Ryzlak, M.T. & Pietruszko, R. (1988). „Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase”. Arch. Biochem. Biophys. 266: 386—396. PMID 3190233.
- ^ Busch, K.B. & Fromm, H. (1999). „Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides”. Plant Physiol. 121: 589—597. PMID 10517851.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Succinate-semialdehyde+dehydrogenase+(NAD+) на US National Library of Medicine Medical Subject Headings (MeSH)
