(Piruvat dehidrogenaza (acetil-transfer)) kinaza

Из Википедије, слободне енциклопедије
(piruvat dehidrogenaza (acetil-transfer)) kinaza
Pyruvate dehydrogenase phosphorylation sites.png
Identifikatori
EC broj 2.7.11.2
CAS broj 2620256
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

(piruvat dehidrogenaza (acetil-transfer)) kinaza (EC 2.7.11.2, PDH kinaza, PDHK, PDK, PDK1, PDK2, PDK3, PDK4, piruvatna dehidrogenaza kinaza, piruvat dehidrogenaza kinaza (fosforilacija), piruvat dehidrogenaza kinaza activator protein, STK1) je enzim sa sistematskim imenom ATP:(piruvat dehidrogenaza (acetil-transfer)) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [piruvat dehidrogenaza (acetil-transfer)] \rightleftharpoons ADP + [piruvat dehidrogenaza (acetil-transfer)] fosfat

Ovaj enzim nema aktivirajuće jedinjenje, ali je specifičan za svoj supstrat.

Reference[уреди]

  1. ^ Linn, T.C., Pelley, J.W., Petit, F.H., Hucho, F., Randall, D.D. and Reed, L.J. (1972). „α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart“. Arch. Biochem. Biophys. 148: 327-342. PMID 4401694. 
  2. ^ Reed, L.J., Damuni, Z. and Merryfield, M.L. (1985). „Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation“. Curr. Top. Cell. Regul. 27: 41-49. PMID 3004826. 
  3. ^ Tovar-Mendez, A., Hirani, T.A., Miernyk, J.A. and Randall, D.D. (2005). „Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase“. Arch. Biochem. Biophys. 434: 159-168. PMID 15629119. 
  4. ^ Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y. and Roche, T.E. (2004). „Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP“. Biochemistry 43: 13442-13451. PMID 15491151. 
  5. ^ Roche, T.E., Hiromasa, Y., Turkan, A., Gong, X., Peng, T., Yan, X., Kasten, S.A., Bao, H. and Dong, J. (2003). „Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1“. Eur. J. Biochem. 270: 1050-1056. PMID 12631265. 

Literatura[уреди]

Spoljašnje veze[уреди]