(Piruvat dehidrogenaza (acetil-transfer)) kinaza

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(piruvat dehidrogenaza (acetil-transfer)) kinaza
Pyruvate dehydrogenase phosphorylation sites.png
Identifikatori
EC broj 2.7.11.2
CAS broj 2620256
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

(piruvat dehidrogenaza (acetil-transfer)) kinaza (EC 2.7.11.2, PDH kinaza, PDHK, PDK, PDK1, PDK2, PDK3, PDK4, piruvatna dehidrogenaza kinaza, piruvat dehidrogenaza kinaza (fosforilacija), piruvat dehidrogenaza kinaza activator protein, STK1) je enzim sa sistematskim imenom ATP:(piruvat dehidrogenaza (acetil-transfer)) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [piruvat dehidrogenaza (acetil-transfer)] ADP + [piruvat dehidrogenaza (acetil-transfer)] fosfat

Ovaj enzim nema aktivirajuće jedinjenje, ali je specifičan za svoj supstrat.

Reference[уреди]

  1. Linn, T.C., Pelley, J.W., Petit, F.H., Hucho, F., Randall, D.D. and Reed, L.J. (1972). „α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart”. Arch. Biochem. Biophys. 148: 327—342. PMID 4401694. 
  2. Reed, L.J., Damuni, Z. and Merryfield, M.L. (1985). „Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation”. Curr. Top. Cell. Regul. 27: 41—49. PMID 3004826. 
  3. Tovar-Mendez, A., Hirani, T.A., Miernyk, J.A. and Randall, D.D. (2005). „Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase”. Arch. Biochem. Biophys. 434: 159—168. PMID 15629119. 
  4. Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y. and Roche, T.E. (2004). „Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP”. Biochemistry. 43: 13442—13451. PMID 15491151. 
  5. Roche, T.E., Hiromasa, Y., Turkan, A., Gong, X., Peng, T., Yan, X., Kasten, S.A., Bao, H. and Dong, J. (2003). „Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1”. Eur. J. Biochem. 270: 1050—1056. PMID 12631265. 

Literatura[уреди]

Spoljašnje veze[уреди]