(S)-hidroksinitrilna lijaza
| (S)-hidroksinitrilna lijaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.1.2.47 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(S)-hidroksinitrilna lijaza (EC 4.1.2.47, (S)-cijanohidrin produkujuća hidroksinitrilna lijaza, (S)-oksinitrilaza, (S)-HbHNL, (S)-MeHNL, hidroksinitrilna lijaza, oksinitrilaza, HbHNL, MeHNL, (S)-selektivna hidroksinitrilna lijaza, (S)-cijanohidrin karbonil-lijaza (formira cijanid)) je enzim sa sistematskim imenom (S)-cijanohidrin lijaza (formira cijanid).[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) alifatični (S)-hidroksinitril cijanid + alifatični aldehid ili keton
- (2) aromatična (S)-hidroksinitril cijanid + aromatični aldehid
Ovaj enzim katalizuje razlaganje hidroksinitrila u cijanid i korespondirajući aldehid ili keton.
Reference[уреди | уреди извор]
- ^ Förster, S., Roos, J., Effenberger, F., Wajant, H. and Sprauer, A. (1996). „The first recombinant hydroxynitrile lyase and its application in the synthesis of (S)-cyanohydrins”. Angew. Chem. Int. Ed. 35: 437—439.
- ^ Bühler, H., Effenberger, F., Förster, S., Roos, J. and Wajant, H. (2003). „Substrate specificity of mutants of the hydroxynitrile lyase from Manihot esculenta”. Chembiochem. 4: 211—216. PMID 12616635.
- ^ Semba, H., Dobashi, Y. and Matsui, T. (2008). „Expression of hydroxynitrile lyase from Manihot esculenta in yeast and its application in (S)-mandelonitrile production using an immobilized enzyme reactor”. Biosci. Biotechnol. Biochem. 72: 1457—1463. PMID 18540112.
- ^ Avi, M., Wiedner, R.M., Griengl, H. and Schwab, H. (2008). „Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4′-oxocyclohexyl)acetonitrile as the model”. Chemistry. 14: 11415—11422. PMID 19006143.
- ^ von Langermann, J., Guterl, J.K., Pohl, M., Wajant, H. and Kragl, U. (2008). „Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values”. Bioprocess Biosyst. Eng. 31: 155—161. PMID 18204865.
- ^ Schmidt, A., Gruber, K., Kratky, C. and Lamzin, V.S. (2008). „Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis”. J. Biol. Chem. 283: 21827—21836. PMID 18524775.
- ^ Gartler, G., Kratky, C. and Gruber, K. (2007). „Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis”. J. Biotechnol. 129: 87—97. PMID 17250917.
- ^ Wagner, U.G., Schall, M., Hasslacher, M., Hayn, M., Griengl, H., Schwab, H. and Kratky, C. (1996). „Crystallization and preliminary X-ray diffraction studies of a hydroxynitrile lyase from Hevea brasiliensis”. Acta Crystallogr. D Biol. Crystallogr. 52: 591—593. PMID 15299689.
- ^ Schmidt, M., Herve, S., Klempier, N. and Griengl, H. (1996). „Preparation of optically active cyanohydrins using the (S)-hydroxynitrile lyase from Hevea brasiliensis”. Tetrahedron. 52: 7833—7840.
- ^ Klempier, N. & Griengl, H. (1993). „Aliphatic (S)-cyanohydrins by enzyme catalyzed synthesis”. Tetrahedron Lett. 34: 4769—4772.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- (S)-hydroxynitrile+lyase на US National Library of Medicine Medical Subject Headings (MeSH)
