5-Epiaristolohenska sintaza

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5-Epiaristolohenska sintaza
Identifikatori
EC broj 4.2.3.61
Baze podataka
IntEnz IntEnz pregled
BRENDA BRENDA pristup
ExPASy NiceZyme pregled
KEGG KEGG pristup
MetaCyc metabolički put
PRIAM profil
Strukture PBP RCSB PDB PDBe PDBsum

5-Epiaristolohenska sintaza (EC 4.2.3.61, 5-epi-aristolohenska sintaza, tobako epiaristolohenska sintaza, farnezil pirofosfatna ciklaza, EAS, TEAS) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-5-epiaristolohen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(2E,6E)-farnezil difosfat (+)-5-epiaristolohen + difosfat

Inicijalna ciklizacija daje (+)-germakren A koji je vezan za enzim.

Reference[уреди]

  1. Back, K., Yin, S. and Chappell, J. (1994). „Expression of a plant sesquiterpene cyclase gene in Escherichia coli”. Arch. Biochem. Biophys. 315: 527—532. PMID 7986100. 
  2. Starks, C.M., Back, K., Chappell, J. and Noel, J.P. (1997). „Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase”. Science. 277: 1815—1820. PMID 9295271. 
  3. Back, K., He, S., Kim, K.U. and Shin, D.H. (1998). „Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in UV-challenged leaves of Capsicum annuum”. Plant Cell Physiol. 39: 899—904. PMID 9816674. 
  4. Rising, K.A., Starks, C.M., Noel, J.P. and Chappell, J. (2000). „Demonstration of germacrene A as an intermediate in 5-epi-aristolochene synthase catalysis”. J. Am. Chem. Soc. 122: 1861—1866. 
  5. Bohlmann, J., Stauber, E.J., Krock, B., Oldham, N.J., Gershenzon, J. and Baldwin, I.T. (2002). „Gene expression of 5-epi-aristolochene synthase and formation of capsidiol in roots of Nicotiana attenuata and N. sylvestris'”. Phytochemistry. 60: 109—116. PMID 12009313. 
  6. O'Maille, P.E., Chappell, J. and Noel, J.P. (2006). „Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase”. Arch. Biochem. Biophys. 448: 73—82. PMID 16375847. 

Literatura[уреди]

Spoljašnje veze[уреди]