5-Epiaristolohenska sintaza

Из Википедије, слободне енциклопедије
5-Epiaristolohenska sintaza
EC broj
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

5-Epiaristolohenska sintaza (EC, 5-epi-aristolohenska sintaza, tobako epiaristolohenska sintaza, farnezil pirofosfatna ciklaza, EAS, TEAS) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-5-epiaristolohen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(2E,6E)-farnezil difosfat \rightleftharpoons (+)-5-epiaristolohen + difosfat

Inicijalna ciklizacija daje (+)-germakren A koji je vezan za enzim.


  1. Back, K., Yin, S. and Chappell, J. (1994). „Expression of a plant sesquiterpene cyclase gene in Escherichia coli”. Arch. Biochem. Biophys. 315: 527-532. PMID 7986100 
  2. Starks, C.M., Back, K., Chappell, J. and Noel, J.P. (1997). „Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase”. Science 277: 1815-1820. PMID 9295271 
  3. Back, K., He, S., Kim, K.U. and Shin, D.H. (1998). „Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in UV-challenged leaves of Capsicum annuum”. Plant Cell Physiol. 39: 899-904. PMID 9816674 
  4. Rising, K.A., Starks, C.M., Noel, J.P. and Chappell, J. (2000). „Demonstration of germacrene A as an intermediate in 5-epi-aristolochene synthase catalysis”. J. Am. Chem. Soc. 122: 1861-1866 
  5. Bohlmann, J., Stauber, E.J., Krock, B., Oldham, N.J., Gershenzon, J. and Baldwin, I.T. (2002). „Gene expression of 5-epi-aristolochene synthase and formation of capsidiol in roots of Nicotiana attenuata and N. sylvestris'”. Phytochemistry 60: 109-116. PMID 12009313 
  6. O'Maille, P.E., Chappell, J. and Noel, J.P. (2006). „Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase”. Arch. Biochem. Biophys. 448: 73-82. PMID 16375847 


Spoljašnje veze[уреди]