Aceglutamid

Aceglutamid
Nazivi
	IUPAC naziv N2-Acetilglutamin
	Drugi nazivi α-N-Acetilglutamin
Identifikacija
CAS broj	2490-97-3 S ;
3D model (Jmol)	interaktivna slika; interaktivna slika;
ChemSpider	23836 ; 392045 R ; 158492 S ;
DrugBank	DB04167 ;
ECHA InfoCard	100.017.862
EC broj	219-647-7
KEGG	D07063 ;
MeSH	aceglutamide
PubChem C ID	25561; 444019 R; 182230 S;
UNII	01J18G9G97 ;
	SMILES Cc(:[o]):[nH]C(CCc(:[nH2]):[o])c(:[o]):[oH]; CC(=O)NC(CCC(N)=O)C(O)=O; ; ; ; ;
Svojstva
Hemijska formula	C7H12N2O4
Molarna masa	188,18 g·mol−1
Agregatno stanje	Beli kristali
Tačka topljenja	197 °C (387 °F; 470 K)
Srodna jedinjenja
Srodne alkanoinske kiseline	N-Acetilaspartinska kiselina; N-Acetilglutaminska kiselina; Citrulin; Pivagabin;
Srodna jedinjenja	Bromizoval; Karbromal;
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

Aceglutamid je psihostimulans i nutropik^[4] koji se koristi za poboljšanje memorije i koncentracije.^[5] Hemijski, on je acetilni derivat aminokiseline L-glutamina.

So aceglutamid aluminijum (KW-110, ili Glumal) je efektivna u tretmanu čireva.^[6]^[7]^[8]^[9]

Aceglutamid se takođe može koristiti kao izvor glutamina koji je stabilian u tečnom stanju.^[10]^[11]^[12]

Reference[уреди | уреди извор]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Susan Budavari, ур. (2001). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th изд.). Merck Publishing. ISBN 0911910131.
^ Macdonald, F, ур. (1997). Dictionary of pharmacological agents. стр. A-00018. ISBN 978-0-412-46630-4.
^ Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). „Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl)”. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 79 (4): 327—34. PMID 7095654.
^ Harada, Masatoshi; Yano, Shingo (1974). „Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW-110) and related compounds on gastric erosion and motility in stressed animals”. Oyo Yakuri. 8 (1): 1—6.
^ Varas Lorenzo, MJ; López Martínez, A; Gordillo Bernal, J; Mundet Surroca, J (1991). „Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer”. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 80 (2): 91—4. PMID 1790087.
^ Tanaka, H; Shuto, K; Marumo, H (1982). „Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats”. Japanese journal of pharmacology. 32 (2): 307—13. PMID 7098147.
^ Lopez-Pedrosa Jose M; Manzano Manuel; Baxter Jeffrey H; Rueda Ricardo (2007). „N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs”. Digestive diseases and sciences. 52 (3): 650—658. PMID 17253138. doi:10.1007/s10620-006-9500-y.
^ JP 10101576
^ US 2003099722

Литература[уреди | уреди извор]

Macdonald, F, ур. (1997). Dictionary of pharmacological agents. стр. A-00018. ISBN 978-0-412-46630-4.

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Susan Budavari, ур. (2001). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th изд.). Merck Publishing. ISBN 0911910131.

[5] Macdonald, F, ур. (1997). Dictionary of pharmacological agents. стр. A-00018. ISBN 978-0-412-46630-4.

[6] Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). „Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl)”. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 79 (4): 327—34. PMID 7095654.

[7] Harada, Masatoshi; Yano, Shingo (1974). „Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW-110) and related compounds on gastric erosion and motility in stressed animals”. Oyo Yakuri. 8 (1): 1—6.

[8] Varas Lorenzo, MJ; López Martínez, A; Gordillo Bernal, J; Mundet Surroca, J (1991). „Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer”. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 80 (2): 91—4. PMID 1790087.

[9] Tanaka, H; Shuto, K; Marumo, H (1982). „Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats”. Japanese journal of pharmacology. 32 (2): 307—13. PMID 7098147.

[10] Lopez-Pedrosa Jose M; Manzano Manuel; Baxter Jeffrey H; Rueda Ricardo (2007). „N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs”. Digestive diseases and sciences. 52 (3): 650—658. PMID 17253138. doi:10.1007/s10620-006-9500-y.

[11] JP 10101576

[12] US 2003099722

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