Akrocilindropepsin
| Akrocilindropepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.28 | ||||||||
| CAS broj | 37288-84-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Akrocilindropepsin (EC 3.4.23.28, Acrocylindrium proteinaza, Acrocylindrium kiselinska proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Postoji preferencija za hidrofobne ostatake u P1 i P1'. Dejstvo na B lanac insulina je generalno slično sa pepsinom A, ali dolazi i do razlaganja Leu6-Cys(SO3H), Glu21-Arg i Asn3-Gln, mada ne Gln4-His
Ovaj enzim je prisutan u glivi Acrocylindrium sp.
Reference[уреди | уреди извор]
- ^ Uchino, F., Kurono, Y. and Doi, S. (1967). „Purification and some properties of crystalline acid protease from Acrocylindrium sp”. Agric. Biol. Chem. 31: 428—434.
- ^ Ichihara, S. & Uchino, F. (1975). „The specificity of acid proteinase from Acrocylindrium”. Agric. Biol. Chem. 39: 423—428.
- ^ Takahashi, K. & Chang, W.-J. (1976). „The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin”. J. Biochem. (Tokyo). 80: 497—506. PMID 10290.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Acrocylindropepsin на US National Library of Medicine Medical Subject Headings (MeSH)
