Aminopeptidaza I
| Aminopeptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.22 | ||||||||
| CAS broj | 9031-94-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminopeptidaza I (EC 3.4.11.22, aminopeptidaza III, aminopeptidaza yscI, leucinska aminopeptidaza IV, kvaščana aminopeptidaza I) je enzim sa sistematskim imenom '.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne aminokiseline, preferentno neutralne ili hidrofobne, sa polipeptida. Aminoacil-arilamidi su slabi supstrati
Ovaj 640 kDa težak dodekamerni enzim je najpoznatiji kao glavna vakuolarna aminopeptidaza kod kvasca.
Reference[уреди | уреди извор]
- ^ Johnson, M.J. (1941). „Isolation and properties of a pure yeast polypeptidase”. J. Biol. Chem. 137: 575—586.
- ^ Metz, G. & Rohm, K.-H. (1976). „Yeast aminopeptidase I. Chemical composition and catalytic properties”. Biochim. Biophys. Acta. 429: 933—949. PMID 5147.
- ^ Chang, Y-H. & Smith, J.A. (1989). „Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae”. J. Biol. Chem. 264: 6979—6983. PMID 2651436.
- ^ Oda, M.N., Scott, S.V., Hefner-Gravink, A., Caffarelli, A.D. and Klionsky, D.J. (1996). „Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I”. J. Cell Biol. 132: 999—1010. PMID 8601598.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Aminopeptidase+I на US National Library of Medicine Medical Subject Headings (MeSH)
