Brahiurin
| Brahiurin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.32 | ||||||||
| CAS broj | 848900-32-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Brahiurin (EC 3.4.21.32, proteaza I raka, proteaza II raka) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću za peptidne veze. Prirodni kolagen se razlaže na oko 75% dužine molekula sa N-terminusa. Niska aktivnost na malim molekulskim supstratima tripsina i himotripsina
Ovaj enzim je izolovan iz raka, Uca pugilator.
Reference[уреди | уреди извор]
- ^ Hurion, N., Fromentin, H. and Keil, B. (1979). „Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus”. Arch. Biochem. Biophys. 192: 438—445. PMID 219780.
- ^ Grant, G.A., Eisen, A.Z. and Bradshaw, R.A. (1981). „Collagenolytic protease from fiddler crab (Uca pugilator)”. Methods Enzymol. 80: 722—734.
- ^ Welgus, H.G., Grant, G.A., Jeffrey, J.J. and Eisen, A.Z. (1982). „Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates”. Biochemistry. 21: 5183—5189. PMID 6756469.
- ^ Welgus, H.G. & Grant, G.A. (1983). „Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator”. Biochemistry. 22: 2228—2233. PMID 6305411.
- ^ Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O. and Strongin, A.Y. (1990). „The isolation and properties of collagenolytic proteases from crab hepatopancreas”. Biochem. Biophys. Res. Commun. 166: 1411—1420. PMID 2154979.
- ^ Lu, P.-J., Liu, H.-C. and Tsai, I.-H. (1990). „The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens”. Biol. Chem. Hoppe-Seyler. 371: 851—859. PMID 1963309.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Brachyurin на US National Library of Medicine Medical Subject Headings (MeSH)
