Interstinalna kolagenaza
(преусмерено са EC 3.4.24.7)
| Interstinalna kolagenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 collagenase monomer, Human fibroblast | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.24.7 | ||||||||
| CAS broj | 2593923 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Interstinalna kolagenaza (EC 3.4.24.7, kolagenaza kičmenjaka, matrična metaloproteinaza 1) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje trostrukog heliksa kolagena na oko tri četvrtine dužine molekula sa N-terminusa, na Gly775-Ile u alfa1(I) lancu. Razlaganje sintetičkih supstrata i alfa-makroglobulina na vezama gde je P1' hidrofoban ostatak
Ovaj enzim je široko rasprostranjen kod kičmenjaka.
Reference[уреди | уреди извор]
- ^ Goldberg, G.I., Wilhelm, S.M., Kronberger, A., Bauer, E.A., Grant, G.A. and Eisen, A.Z. (1986). „Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein”. J. Biol. Chem. 261: 6600—6605. PMID 3009463.
- ^ Birkedal-Hansen, H. (1987). „Catabolism and turnover of collagens: collagenases”. Methods Enzymol. 144: 140—171. PMID 3041177.
- ^ Fields, G.B., Van Wart, H.E. and Birkedal-Hansen, H. (1987). „Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site”. J. Biol. Chem. 262: 6221—6226. PMID 3032960.
- ^ Sottrup-Jensen, L. & Birkedal-Hansen, H. (1989). „Human fibroblast collagenase-α-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian α-macroglobulins”. J. Biol. Chem. 264: 393—401. PMID 2462561.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Interstitial+collagenase на US National Library of Medicine Medical Subject Headings (MeSH)
