Endodezoksiribonukleaza krosing-overnog čvora
| Endodezoksiribonukleaza krosing-overnog čvora | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.1.22.4 | ||||||||
| CAS broj | 99676-43-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Endodezoksiribonukleaza krosing-overnog čvora (EC 3.1.22.4, Hje endonukleaza, endonukleaza Holidejovog spoja CCE1, rezolvaza Holidejovog spoja, endonukleaza razlaganja Holidejovog spoja, Holidejov spoj razlažuća endoribonukleaza, RusA Holidejov spoj rezolvaza, RusA endonukleaza, RuvC endonukleaza, SpCCe1 Holidejov spoj rezolvaza, endoribonukleaza krosing-over spoja, endonukleaza presecanja kruciforma, endo X3, endonukleaza RuvC, endonukleaza VII, endonukleaza X3) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endonukleolitičko razlaganje na račvama kao što su recipročni jednolančani krosing-overi između dva homologna DNK dupleksa (Holidejov spoj)
Enzim iz Saccharomyces cerevisiae ne deluje kao endonukleaza ili eksonukleaza na DNK molekulima koji ne sadrže Holidejov spoj.
Reference[уреди | уреди извор]
- ^ Symington, L.S. & Kolodner, R. (1985). „Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions”. Proc. Natl. Acad. Sci. USA. 82: 7247—7251. PMID 3903750.
- ^ Shida, T., Iwasaki, H., Saito, A., Kyogoku, Y. and Shinagawa, H. (1996). „Analysis of substrate specificity of the RuvC holliday junction resolvase with synthetic Holliday junctions”. J. Biol. Chem. 271: 26105—26109. PMID 8824253.
- ^ Shah, R., Cosstick, R. and West, S.C. (1997). „The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts”. EMBO J. 16: 1464—1472. PMID 9135161.
- ^ Fogg, J.M., Schofield, M.J., White, M.F. and Lilley, D.M. (1999). „Sequence and functional-group specificity for cleavage of DNA junctions by RuvC of Escherichia coli”. Biochemistry. 38: 11349—11358. PMID 10471285.
- ^ Middleton, C.L., Parker, J.L., Richard, D.J., White, M.F. and Bond, C.S. (2003). „Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus”. Acta Crystallogr. D Biol. Crystallogr. 59: 171—173. PMID 12499561.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Crossover+junction+endodeoxyribonuclease на US National Library of Medicine Medical Subject Headings (MeSH)
