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GIPC1

С Википедије, слободне енциклопедије
GIPC familija koja sadrži PDZ domen, član 1
Identifikatori
Simboli GIPC1; C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP-1; NIP; RGS19IP1; SEMCAP; SYNECTIIN; SYNECTIN; TIP-2
Vanjski ID OMIM605072 MGI1926252 HomoloGene21167 GeneCards: GIPC1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 10755 67903
Ensembl ENSG00000123159 ENSMUSG00000019433
UniProt O14908 Q9Z0G0
RefSeq (mRNA) NM_005716.3 NM_018771.3
RefSeq (protein) NP_005707.1 NP_061241.1
Lokacija (UCSC) Chr 19:
14.59 - 14.61 Mb
Chr 8:
83.65 - 83.66 Mb
PubMed pretraga [1] [2]

GIPC1 (GIPC familija koja sadrži PDZ domen, član 1) je protein koji je kod ljudi kodiran GIPC1 genom.[1][2][3]

GIPC1 formira interakcije sa Beta-1 adrenergičkim receptorom,[4] ITGA5,[5] ITGA6,[5] TPBG,[6] RGS19,[7] TYRP1,[8] GLUT1,[9] Aktinin, alfa 1,[9] KIF1B,[9] LRP2,[10][11][12] LHCGR,[13] LRP1[10] i MYO6.[14][15]

  1. ^ De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG (1998). „GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP”. Proc Natl Acad Sci U S A. 95 (21): 12340—5. PMC 22833Слободан приступ. PMID 9770488. doi:10.1073/pnas.95.21.12340. 
  2. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (1998). „The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins”. Oncogene. 16 (5): 643—54. PMID 9482110. doi:10.1038/sj.onc.1201567. 
  3. ^ „Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1”. 
  4. ^ Hu Liaoyuan A; Chen Wei; et al. (2003). „GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation”. J. Biol. Chem. United States. 278 (28): 26295—301. ISSN 0021-9258. PMID 12724327. doi:10.1074/jbc.M212352200. 
  5. ^ а б Tani, T T; Mercurio A M (2001). „PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B”. J. Biol. Chem. United States. 276 (39): 36535—42. ISSN 0021-9258. PMID 11479315. doi:10.1074/jbc.M105785200. 
  6. ^ Awan, Abida; Lucic Melinda R; et al. (2002). „5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis”. Biochem. Biophys. Res. Commun. United States. 290 (3): 1030—6. ISSN 0006-291X. PMID 11798178. doi:10.1006/bbrc.2001.6288. 
  7. ^ Lou, X; Yano H; et al. (2001). „GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways”. Mol. Biol. Cell. United States. 12 (3): 615—27. ISSN 1059-1524. PMC 30968Слободан приступ. PMID 11251075. 
  8. ^ Liu, T F; Kandala G; Setaluri V (2001). „PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)”. J. Biol. Chem. United States. 276 (38): 35768—77. ISSN 0021-9258. PMID 11441007. doi:10.1074/jbc.M103585200. 
  9. ^ а б в Bunn, R C; Jensen M A; Reed B C (1999). „Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton”. Mol. Biol. Cell. UNITED STATES. 10 (4): 819—32. ISSN 1059-1524. PMC 25204Слободан приступ. PMID 10198040. 
  10. ^ а б Gotthardt, M; Trommsdorff M; et al. (2000). „Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction”. J. Biol. Chem. UNITED STATES. 275 (33): 25616—24. ISSN 0021-9258. PMID 10827173. doi:10.1074/jbc.M000955200. 
  11. ^ Petersen, Helle Heibroch; Hilpert Jan; et al. (2003). „Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule”. J. Cell. Sci. England. 116 (Pt 3): 453—61. ISSN 0021-9533. PMID 12508107. doi:10.1242/jcs.00243. 
  12. ^ Lou, Xiaojing; McQuistan Tammie; et al. (2002). „GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function”. J. Am. Soc. Nephrol. United States. 13 (4): 918—27. ISSN 1046-6673. PMID 11912251. 
  13. ^ Hirakawa, Takashi; Galet Colette; et al. (2003). „GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR”. J. Biol. Chem. United States. 278 (49): 49348—57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200. 
  14. ^ Ewing, Rob M; Chu Peter; et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. England. 3 (1): 89. PMC 1847948Слободан приступ. PMID 17353931. doi:10.1038/msb4100134. 
  15. ^ Aschenbrenner, Laura; Lee TinThu; Hasson Tama (2003). „Myo6 facilitates the translocation of endocytic vesicles from cell peripheries”. Mol. Biol. Cell. United States. 14 (7): 2728—43. ISSN 1059-1524. PMC 165672Слободан приступ. PMID 12857860. doi:10.1091/mbc.E02-11-0767.