HSPA1A
| Protein toplotnog šoka 70 kDa 1A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| Dostupne strukture | |||||||||||
| 1hjo, 1s3x, 1xqs | |||||||||||
| Identifikatori | |||||||||||
| Simboli | HSPA1A; HSP70-1; HSP72; HSPA1; HSPA1B; HSPA1A; HSP70-2 | ||||||||||
| Vanjski ID | OMIM: 140550 MGI: 99517 HomoloGene: 74294 GeneCards: HSPA1A Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3303 | 15511 | |||||||||
| Ensembl | ENSG00000204389 | ENSMUSG00000067284 | |||||||||
| UniProt | P08107 | O88687 | |||||||||
| RefSeq (mRNA) | NM_005345 | XM_001002795 | |||||||||
| RefSeq (protein) | NP_005336 | XP_001002795 | |||||||||
| Lokacija (UCSC) |
Chr 6: 31.78 - 31.79 Mb |
Chr 17: 34.57 - 34.57 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
HSPA1A, protein toplotnog šoka 70 kDa 1, je protein koji je kod čoveka kodiran HSPA1A genom.
Ovaj gen ne sadrži introne. On je član familije proteina toplotnog šoka 70. Zajedno s drugim proteinima toplotnog šoka, ovaj protein sprečava agregaciju postojećih proteina i posreduje savijanje novo transliranih proteina u citosolu i organelama. On takođe učestvuje u ubikvitin-proteasom putu tako što ostvaruje interakcije sa AU-bogatim elementom RNK-vezujućeg proteina 1. Ovaj gen je lociran u regionu klase III glavnog histokompatibilnostnog kompleksa, u klasteru sa dva blisko srodna gena koji kodiraju slične proteine.[1]
Interakcije[уреди | уреди извор]
Za HSPA1A je bilo pokazano da interaguje sa ASK1,[2] STUB1,[3][4] MSR1,[5] BAG3,[6][7] Parkinovom ligazom,[4] Fankonijeva anemija, komplementaciona grupa C,[8][9] GPR37,[4] HSF1[10][11] i AIFM1.[12][13]
Reference[уреди | уреди извор]
- ^ „Entrez Gene: HSPA1A heat shock 70kDa protein 1A”.
- ^ Park, Hee-Sae; Cho Ssang-Goo; et al. (2002). „Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1”. Mol. Cell. Biol. United States. 22 (22): 7721—30. ISSN 0270-7306. PMC 134722
. PMID 12391142. doi:10.1128/MCB.22.22.7721-7730.2002.
- ^ Ballinger, C A; Connell P; et al. (1999). „Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Mol. Cell. Biol. UNITED STATES. 19 (6): 4535—45. ISSN 0270-7306. PMC 104411 . PMID 10330192.
- ^ а б в Imai, Yuzuru; Soda Mariko; et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell. United States. 10 (1): 55—67. ISSN 1097-2765. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
- ^ Nakamura, Toshinobu; Hinagata Jun-ichi; et al. (2002). „HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors”. Biochem. Biophys. Res. Commun. United States. 290 (2): 858—64. ISSN 0006-291X. PMID 11785981. doi:10.1006/bbrc.2001.6271.
- ^ Doong, H; Price J; et al. (2000). „CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70”. Oncogene. ENGLAND. 19 (38): 4385—95. ISSN 0950-9232. PMID 10980614. doi:10.1038/sj.onc.1203797.
- ^ Antoku, K; Maser R S; et al. (2001). „Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein”. Biochem. Biophys. Res. Commun. United States. 286 (5): 1003—10. ISSN 0006-291X. PMID 11527400. doi:10.1006/bbrc.2001.5512.
- ^ Pang, Qishen; Christianson Tracy A; et al. (2002). „The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC”. J. Biol. Chem. United States. 277 (51): 49638—43. ISSN 0021-9258. PMID 12397061. doi:10.1074/jbc.M209386200.
- ^ Reuter, Tanja Y; Medhurst Annette L; et al. (2003). „Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport”. Exp. Cell Res. United States. 289 (2): 211—21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1.
- ^ Shi, Y; Mosser D D; Morimoto R I (1998). „Molecular chaperones as HSF1-specific transcriptional repressors”. Genes Dev. UNITED STATES. 12 (5): 654—66. ISSN 0890-9369. PMC 316571 . PMID 9499401.
- ^ Zhou, X; Tron V A; et al. (1998). „Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light”. J. Invest. Dermatol. UNITED STATES. 111 (2): 194—8. ISSN 0022-202X. PMID 9699716. doi:10.1046/j.1523-1747.1998.00266.x.
- ^ Ruchalski, Kathleen; Mao Haiping; et al. (2003). „HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells”. Am. J. Physiol., Cell Physiol. United States. 285 (6): C1483—93. ISSN 0363-6143. PMID 12930708. doi:10.1152/ajpcell.00049.2003.
- ^ Ravagnan, L; Gurbuxani S; et al. (2001). „Heat-shock protein 70 antagonizes apoptosis-inducing factor”. Nat. Cell Biol. England. 3 (9): 839—43. ISSN 1465-7392. PMID 11533664. doi:10.1038/ncb0901-839.
Literatura[уреди | уреди извор]
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- Milner CM, Campbell RD (1990). „Structure and expression of the three MHC-linked HSP70 genes.”. Immunogenetics. 32 (4): 242—51. PMID 1700760. doi:10.1007/BF00187095.
- Sargent CA, Dunham I, Trowsdale J, Campbell RD (1989). „Human major histocompatibility complex contains genes for the major heat shock protein HSP70.”. Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1968—72. PMC 286826 . PMID 2538825. doi:10.1073/pnas.86.6.1968.
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- Goate AM; Cooper DN; Hall C; et al. (1987). „Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis.”. Hum. Genet. 75 (2): 123—8. PMID 2880793. doi:10.1007/BF00591072.
- Hickey E; Brandon SE; Sadis S; et al. (1986). „Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia.”. Gene. 43 (1-2): 147—54. PMID 3019832. doi:10.1016/0378-1119(86)90018-1.
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Spoljašnje veze[уреди | уреди извор]
- HSPA1A+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
