Kliohinol

Kliohinol
Klinički podaci
Prodajno ime	Ala-quin, Alchloquin, Alioform, Amebil
Drugs.com	Monografija
Identifikatori
CAS broj	130-26-7
ATC kod	P01AA02 (WHO), D09AA10
PubChem	CID 2788
DrugBank	DB04815
ChemSpider	2686
ChEMBL	CHEMBL497
Hemijski podaci
Formula	C9H5ClINO
Molarna masa	305,500
	SMILES OC1=C(I)C=C(Cl)C2=C1N=CC=C2; ;
	InChI InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H ; Key:QCDFBFJGMNKBDO-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	1.785 °C (3.245 °F)

Kliohinol je organsko jedinjenje, koje sadrži 9 atoma ugljenika i ima molekulsku masu od 305,500 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	1
Broj rotacionih veza	0
Particioni koeficijent^[8] (ALogP)	3,0
Rastvorljivost^[9] (logS, log(mol/L))	-4,0
Polarna površina^[10] (PSA, Å²)	33,1

Reference

^ Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W: Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus. Antimicrob Agents Chemother. Rohde, W.; Mikelens, P.; Jackson, J.; Blackman, J.; Whitcher, J.; Levinson, W. (август 1976). „Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus”. Antimicrobial Agents and Chemotherapy. 10 (2): 234—40. PMC 429727 . PMID 185949. doi:10.1128/AAC.10.2.234.
^ GHOLZ LM, ARONS WL: PROPHYLAXIS AND THERAPY OF AMEBIASIS AND SHIGELLOSIS WITH IODOCHLORHYDROXYQUIN. Am J Trop Med Hyg. ;13:396-401. GHOLZ LM; ARONS WL (1964 May). „Prophylaxis and Therapy of Amebiasis and Shigellosis with Iodochlorhydroxyquin”. The American Journal of Tropical Medicine and Hygiene. 13 (3): 396—401. PMID 14162901. doi:10.4269/ajtmh.1964.13.396. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Kager PA: [Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby] Ned Tijdschr Geneeskd. Kager, P. A. (јануар 2005). „Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby”. Nederlands Tijdschrift voor Geneeskunde. 149 (1): 51—2. PMID 15651505. ; author reply 52-3.
^ Bosman DK, Benninga MA, van de Berg P, Kooijman GC, van Gool T: [Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children] Ned Tijdschr Geneeskd. Bosman, D. K.; Benninga, M. A.; Van De Berg, P.; Kooijman, G. C.; Van Gool, T. (март 2004). „Dientamoeba fragilis: Possibly an important cause of persistent abdominal pain in children”. Nederlands Tijdschrift voor Geneeskunde. 148 (12): 575—9. PMID 15074181.
^ Masters DK, Hopkins AD: Therapeutic trial of four amoebicide regimes in rural Zaire. J Trop Med Hyg. Masters, D. K.; Hopkins, A. D. (мај 1979). „Therapeutic trial of four amoebicide regimes in rural Zaire”. The Journal of Tropical Medicine and Hygiene. 82 (5): 99—101. PMID 226725.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Clioquinol

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W: Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus. Antimicrob Agents Chemother. Rohde, W.; Mikelens, P.; Jackson, J.; Blackman, J.; Whitcher, J.; Levinson, W. (август 1976). „Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus”. Antimicrobial Agents and Chemotherapy. 10 (2): 234—40. PMC 429727 . PMID 185949. doi:10.1128/AAC.10.2.234.

[2] GHOLZ LM, ARONS WL: PROPHYLAXIS AND THERAPY OF AMEBIASIS AND SHIGELLOSIS WITH IODOCHLORHYDROXYQUIN. Am J Trop Med Hyg. ;13:396-401. GHOLZ LM; ARONS WL (1964 May). „Prophylaxis and Therapy of Amebiasis and Shigellosis with Iodochlorhydroxyquin”. The American Journal of Tropical Medicine and Hygiene. 13 (3): 396—401. PMID 14162901. doi:10.4269/ajtmh.1964.13.396. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Kager PA: [Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby] Ned Tijdschr Geneeskd. Kager, P. A. (јануар 2005). „Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby”. Nederlands Tijdschrift voor Geneeskunde. 149 (1): 51—2. PMID 15651505. ; author reply 52-3.

[4] Bosman DK, Benninga MA, van de Berg P, Kooijman GC, van Gool T: [Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children] Ned Tijdschr Geneeskd. Bosman, D. K.; Benninga, M. A.; Van De Berg, P.; Kooijman, G. C.; Van Gool, T. (март 2004). „Dientamoeba fragilis: Possibly an important cause of persistent abdominal pain in children”. Nederlands Tijdschrift voor Geneeskunde. 148 (12): 575—9. PMID 15074181.

[5] Masters DK, Hopkins AD: Therapeutic trial of four amoebicide regimes in rural Zaire. J Trop Med Hyg. Masters, D. K.; Hopkins, A. D. (мај 1979). „Therapeutic trial of four amoebicide regimes in rural Zaire”. The Journal of Tropical Medicine and Hygiene. 82 (5): 99—101. PMID 226725.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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