Metdilazin

Metdilazin
Klinički podaci
Prodajno ime	Bristaline, Dilosyn, Disyncram, Disyncran
Drugs.com	Monografija
Identifikatori
CAS broj	1982-37-2
ATC kod	R06AD04 (WHO)
PubChem	CID 14677
DrugBank	DB00902
ChemSpider	14009
KEGG	C07175
ChEMBL	CHEMBL1200959
Hemijski podaci
Formula	C18H20N2S
Molarna masa	296,430
	SMILES CN1CCC(CN2C3=CC=CC=C3SC3=CC=CC=C23)C1; ;
	InChI InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 ; Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	87—88 °C (189—190 °F)

Metdilazin je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 296,430 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	0
Broj rotacionih veza	2
Particioni koeficijent^[6] (ALogP)	4,1
Rastvorljivost^[7] (logS, log(mol/L))	-3,9
Polarna površina^[8] (PSA, Å²)	31,8

Reference

^ Rani Basu L, Mazumdar K, Dutta NK, Karak P, Dastidar SG: Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res. 2005;Rani Basu, L.; Mazumdar, K.; Dutta, N. K.; Karak, P.; Dastidar, S. G. (2005). „Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine”. Microbiological Research. 160 (1): 95—100. PMID 15782943. doi:10.1016/j.micres.2004.10.002.
^ Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998 Jul). „Altered membrane permeability as the basis of bactericidal action of methdilazine”. J Antimicrob Chemother. 42 (1): 83—6. PMID 9700532. doi:10.1093/jac/42.1.83. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Chattopadhyay D, Dastidar SG, Chakrabarty AN: Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung. Chattopadhyay, D.; Dastidar, S. G.; Chakrabarty, A. N. (1988 Jul). „Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents”. Arzneimittel-Forschung. 38 (7): 869—72. PMID 2905130. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Methdilazine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rani Basu L, Mazumdar K, Dutta NK, Karak P, Dastidar SG: Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res. 2005;Rani Basu, L.; Mazumdar, K.; Dutta, N. K.; Karak, P.; Dastidar, S. G. (2005). „Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine”. Microbiological Research. 160 (1): 95—100. PMID 15782943. doi:10.1016/j.micres.2004.10.002.

[2] Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998 Jul). „Altered membrane permeability as the basis of bactericidal action of methdilazine”. J Antimicrob Chemother. 42 (1): 83—6. PMID 9700532. doi:10.1093/jac/42.1.83. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Chattopadhyay D, Dastidar SG, Chakrabarty AN: Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung. Chattopadhyay, D.; Dastidar, S. G.; Chakrabarty, A. N. (1988 Jul). „Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents”. Arzneimittel-Forschung. 38 (7): 869—72. PMID 2905130. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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