Miozin laki lanac kinaza
| Miozin laki lanac kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.11.18 | ||||||||
| CAS broj | 51845-53-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Miozin laki lanac kinaza (EC 2.7.11.18, (miozin-laki-lanac) kinaza, ATP:miozin-laki-lanac O-fosfotransferaza, kinaza kalcium/kalmodulin-zavisnog miozinskog lakog lanaca, MLCK, MLCKaza, miozinska kinaza, kinaza miozinskog lakog lanca, proteinska kinaza miozinskog lakog lanca, kinaza miozinskog lakog-lanca (fosforilacija), kinaza glatko mišičnog miozina lakog-lanca, STK18) je enzim sa sistematskim imenom ATP:(miozin laki lanac) O-fosfotransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za rad ovog enzima je neophodan jon Ca2+ i kalmodulin.
Reference
[уреди | уреди извор]- ^ Adelstein, R.S. & Klee, C.B. (1981). „Purification and characterization of smooth muscle myosin light chain kinase”. J. Biol. Chem. 256: 7501—7509. PMID 6894756.
- ^ Hathaway, D.R. & Adelstein, R.S. (1979). „Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity”. Proc. Natl. Acad. Sci. USA. 76: 1653—1657. PMID 156362.
- ^ Pires, E., Perry, S.V. and Thomas, M.A.W. (1974). „Myosin light-chain kinase, a new enzyme from striated muscle”. FEBS Lett. 41: 292—296. PMID 4853304.
- ^ Nunnally, M.H., Rybicki, S.B. and Stull, J.T. (1985). „Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes”. J. Biol. Chem. 260: 1020—1026. PMID 3881420.
- ^ Edelman, A.M., Takio, K., Blumenthal, D.K., Hansen, R.S., Walsh, K.A., Titani, K. and Krebs, E.G. (1985). „Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase”. J. Biol. Chem. 260: 11275—11285. PMID 3897230.
- ^ Mal, T.K., Skrynnikov, N.R., Yap, K.L., Kay, L.E. and Ikura, M. (2002). „Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR”. Biochemistry. 41: 12899—12906. PMID 12390014.
- ^ Sobieszek, A. (1999). „Enzyme kinetic characterization of the smooth muscle myosin phosphorylating system: activation by calcium and calmodulin and possible inhibitory mechanisms of antagonists”. Biochim. Biophys. Acta. 1450: 77—91. PMID 10231558.
- ^ Sobieszek, A., Borkowski, J. and Babiychuk, V.S. (1997). „Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex”. J. Biol. Chem. 272: 7034—7041. PMID 9054394.
- ^ Fujita, K., Ye, L.H., Sato, M., Okagaki, T., Nagamachi, Y. and Kohama, K. (1999). „Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin”. Mol. Cell. Biochem. 190: 85—90. PMID 10098974.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Myosin-light-chain+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
