P-glikoprotein

Из Википедије, слободне енциклопедије
ATP-vezujuća kaseta, potfamilija B (MDR/TAP), član 1
Kristalografska struktura MDR3 proteina miša. Aproksimativna pozicija proteina u ćelijskoj membrani je obeležena plavim (ekstracelularno lice) i crvenim (citoplazmatično lice) linijama. Protein je prikaza u bojama duge (N-terminus = plavo, C-terminus = crveno). Ciklični peptidni inhibitor QZ59 je prikazan kao prostorno popunjavajući model.[1]
Dostupne strukture
3G5U, 3G60, 3G61
Identifikatori
Simboli ABCB1; ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Vanjski ID OMIM171050 MGI97570 HomoloGene55496 GeneCards: ABCB1 Gene
EC broj 3.6.3.44
Pregled RNK izražavanja
PBB GE ABCB1 209994 s at tn.png
PBB GE ABCB1 209993 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5243 18671
Ensembl ENSG00000085563 ENSMUSG00000040584
UniProt P08183 P21447
RefSeq (mRNA) NM_000927.4 NM_011076.2
RefSeq (protein) NP_000918.2 NP_035206.2
Lokacija (UCSC) Chr 7:
87.13 - 87.34 Mb
Chr 5:
8.66 - 8.75 Mb
PubMed pretraga [1] [2]

P-glikoprotein 1 (glikoprotein permeabilnosti, P-gp, Pgp, protein otpornosti na višestruke lekove 1, MDR1, ATP-vezujuća kaseta potfamilija B član 1, ABCB1, klaster of diferencijacije 243, CD243) je glikoprotein koji je kod ljudi kodiran ABCB1 genom.[2] P-gp dobro poznati ABC-transporter (koji transportuje široki opseg supstrata kroz ekstra- i intracelularne membrane). On je član MDR/TAP familije.[3]

Pgp je široko rasprostranjen i izražen u interstinalnom epitelu, hepatocitima, renalno proksimalno tubularnim ćelijama, nadbubrežnoj žlezdi i kapilarnim endotelnim ćelijama od kojih je formirana krvno-moždana i krvno-testikularna barijera.

Reference[уреди]

  1. PDB 3G60; Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G (2009). „Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding”. Science. 323 (5922): 1718—22. doi:10.1126/science.1168750. PMC 2720052слободно за читање. PMID 19325113. 
  2. Ueda K, Clark DP, Chen CJ, Roninson IB, Michael M. Gottesman, Pastan I (1987). „The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation”. J. Biol. Chem. 262 (2): 505—8. PMID 3027054. 
  3. Dean, Michael (1. 11. 2002). „The Human ATP-Binding Cassette (ABC) Transporter Superfamily”. National Library of Medicine (US), NCBI. Приступљено 2. 3. 2008. 

Literatura[уреди]

  • Ling V (1997). „Multidrug resistance: molecular mechanisms and clinical relevance”. Cancer Chemother. Pharmacol. 40 Suppl (7): S3—8. doi:10.1007/s002800051053. PMID 9272126. 
  • Kerb R, Hoffmeyer S, Brinkmann U (2001). „ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2”. Pharmacogenomics. 2 (1): 51—64. doi:10.1517/14622416.2.1.51. PMID 11258197. 
  • Akiyama S (2002). „[Mechanisms of drug resistance and reversal of the resistance]”. Hum. Cell. 14 (4): 257—60. PMID 11925925. 
  • Brinkmann U (2002). „Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo”. Novartis Found. Symp. Novartis Foundation Symposia. 243: 207—10; discussion 210—2, 231—5. doi:10.1002/0470846356.ch15. ISBN 978-0-470-84635-3. PMID 11990778. 
  • Váradi A, Szakács G, Bakos E, Sarkadi B (2002). „P glycoprotein and the mechanism of multidrug resistance”. Novartis Found. Symp. Novartis Foundation Symposia. 243: 54—65; discussion 65—8, 180—5. doi:10.1002/0470846356.ch5. ISBN 978-0-470-84635-3. PMID 11990782. 
  • Hegedus T, Orfi L, Seprodi A; et al. (2002). „Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1”. Biochim. Biophys. Acta. 1587 (2–3): 318—25. PMID 12084474. 
  • Pallis M, Turzanski J, Higashi Y, Russell N (2003). „P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype”. Leuk. Lymphoma. 43 (6): 1221—8. doi:10.1080/10428190290026277. PMID 12152989. 
  • Schaich M, Illmer T (2003). „Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia”. Leuk. Lymphoma. 43 (7): 1345—54. doi:10.1080/10428190290033279. PMID 12389613. 
  • Fromm MF (2003). „The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans”. Adv. Drug Deliv. Rev. 54 (10): 1295—310. doi:10.1016/S0169-409X(02)00064-9. PMID 12406646. 
  • Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Michael M. Gottesman (2003). „P-glycoprotein: from genomics to mechanism”. Oncogene. 22 (47): 7468—85. doi:10.1038/sj.onc.1206948. PMID 14576852. 
  • Jamroziak K, Robak T (2004). „Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies”. Hematology. 9 (2): 91—105. doi:10.1080/10245330310001638974. PMID 15203864. 
  • Ishikawa T, Onishi Y, Hirano H; et al. (2005). „Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1)”. Biol. Pharm. Bull. 27 (7): 939—48. doi:10.1248/bpb.27.939. PMID 15256718. 
  • Lee W, Lockhart AC, Kim RB, Rothenberg ML (2005). „Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development”. Oncologist. 10 (2): 104—11. doi:10.1634/theoncologist.10-2-104. PMID 15709212. 
  • Gambrelle J, Labialle S, Dayan G; et al. (2005). „[Multidrug resistance in uveal melanoma.]”. Journal français d'ophtalmologie. 28 (6): 652—9. PMID 16141933. 
  • Al-Shawi MK, Omote H (2006). „The Remarkable Transport Mechanism of P-glycoprotein; a Multidrug Transporter”. J. Bioenerg. Biomembr. 37 (6): 489—96. doi:10.1007/s10863-005-9497-5. PMC 1459968слободно за читање. PMID 16691488. 
  • Orlowski S, Martin S, Escargueil A (2006). „P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?)”. Cell. Mol. Life Sci. 63 (9): 1038—59. doi:10.1007/s00018-005-5554-9. PMID 16721513. 
  • Annese V, Valvano MR, Palmieri O; et al. (2006). „Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis”. World J. Gastroenterol. 12 (23): 3636—44. PMID 16773678. 
  • Sekine I, Minna JD, Nishio K; et al. (2007). „A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer”. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 1 (1): 31—7. PMID 17409824. 
  • Kumar YS, Adukondalu D, Sathish D, Vishnu YV, Ramesh G, Latha AB, Reddy PC, Sarangapani M, Rao YM (2010). „P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions”. Drug Metabol Drug Interact. 25 (1-4): 3—16. doi:10.1515/DMDI.2010.006. PMID 21417789. 

Spoljašnje veze[уреди]